Journal Pre-proof Effective hybrid approach for protein structure prediction in a two-dimensional Hydrophobic–Polar model Cheng-Hong Yang, Yu-Shiun Lin, Li-Yeh Chuang, Yu-Da Lin PII: S0010-4825(19)30274-4 DOI: https://doi.org/10.1016/j.compbiomed.2019.103397 Reference: CBM 103397 To appear in: Computers in Biology and Medicine Received Date: 15 May 2019 Revised Date: 19 August 2019 Accepted Date: 19 August 2019 Please cite this article as: C.-H. Yang, Y.-S. Lin, L.-Y. Chuang, Y.-D. Lin, Effective hybrid approach for protein structure prediction in a two-dimensional Hydrophobic–Polar model, Computers in Biology and Medicine (2019), doi: https://doi.org/10.1016/j.compbiomed.2019.103397. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier Ltd.