253 Sari Pediatri, Vol. 24, No. 4, Desember 2022 Hubungan Durasi Terapi Asam Valproat dengan Kadar Asam Folat Darah pada Epilepsi Anak Fitry Nur Furaida, 1 Madarina Julia, 2 Agung Triono 2 1 Mahasiswa Magister Ilmu Kedokteran Klinis Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, 2 Departemen Ilmu Kesehatan Anak Universitas Gadjah Mada, Yogyakarta Latar belakang. Penurunan kadar asam folat darah mengakibatkan kondisi perubahan mental, penurunan kognitif, anemia megaloblastik, hiperhomosistein, dan perburukan kendali kejang. Penelitian mengenai efek asam valproat terhadap kadar asam folat belum menunjukkan hasil yang konsisten. Sebagai obat anti epilepsi (OAE) lini pertama pada anak, penelitian pada anak penyandang epilepsi di Indonesia perlu dilakukan. Tujuan. Untuk mengetahui hubungan durasi terapi OAE asam valproat dan kadar asam folat darah pada anak penyandang epilepsi. Metode. Penelitian potong lintang pada bulan Oktober-November 2021 di poliklinik neurologi anak RSUP. Dr. Sardjito Yogyakarta. Subjek 28 penyandang epilepsi dengan monoterapi asam valproat, diperiksa kadar serum asam folat setelah puasa 10 jam. Uji korelasi dilakukan dengan metode Pearson. Analisis multivariat regresi linier dilakukan terhadap faktor perancu yang tidak dapat direstriksi. Nilai p<0,05 dianggap bermakna secara statistik. Hasil. Sebanyak 28 subjek penelitian dengan rerata durasi terapi 31,04±19,47 bulan. Diperoleh rerata kadar asam folat sebesar 19,5±6,47 ng/ml. Tidak ada hubungan antara durasi terapi dan kadar asam folat (r=0,045, p=0,819). Kesimpulan. Penyandang epilepsi dengan monoterapi asam valproat memiliki kadar asam folat pada rentang normal. Durasi terapi asam valptoat tidak mempengaruhi kadar asam folat. Sari Pediatri 2022;24(4):253-8 Kata kunci: asam valproat, durasi, kadar folat, epilepsi, anak Correlation between Duration of Valproic Acid Therapy and Serum Folate Level in Childhood Epilepsy Fitry Nur Furaida, 1 Madarina Julia, 2 Agung Triono 2 Background. Folic acid deficiency may cause altered mental status, declining cognitive function, megaloblastic anemia, hyperhomocysteinemia and worsening seizure. Previous studies regarding the effects of valproic acid on folic acid levels have inconsistent results. As a first-line antiepileptic drug (AED) in children, research on Indonesian children with epilepsy need to be conducted. Objective. To determine correlation between duration of valproic acid therapy and serum folate level in children with epilepsy. Method. Cross-sectional study in October-November 2021 at pediatric-neurology outpatient-clinic of Dr. Sardjito Hospital, Yogyakarta, 28 epilepsy children received valproic acid monotherapy and were examined for serum folate levels after 10 hours of fasting. The correlation between therapy duration and folic acid level was analyzed using Pearson’s tests. Multivariate linear regression was performed on non-restricted confounding factors. p value of <0.05 is considered statistically significant. Results. A total of 28 subjects were recruited, with mean treatment duration of 31,04±19,47 months and folic acid level of 19.5±6.47 ng/ ml. There were no correlations between the duration of therapy with folic acid levels (r=0,045, p=0,819). Conclusions. Epilepsy children with valproic acid monotherapy had folic acid levels within normal range. The duration of valproic acid therapy did not influence the folic acid level. Sari Pediatri 2022;24(4):253-8 Keywords: valproic acid, duration, folate level, epilepsy, children Alamat korespondensi: Fitry Nur Furaida. Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan Universitas Gadjah Mada, Yogyakarta. Jl. Farmako, Sekip Utara, Kec. Depok, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55281. Email: fitrynurfuraida@gmail.com