This is the peer reviewed version of the following article: Bchetnia M, Lacroix J, Farez T, Larouche M, Powell J, McCuaig C, Dupéré A, Morin C, Legendre- Guillemin V et Laprise C. 2015. Reduction in keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide. Experimental Dermatology. Which has been published in final form at http://dx.doi.org/10.1111/exd.12821 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."