Page 1 L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists QI SHI, JASON E. SAVAGE, SANDRA J. HUFEISEN, LAURA RAUSER, EWA GRAJKOWSKA, PAUL ERNSBERGER, JARDA T. WROBLEWSKI, JOSEPH H. NADEAU AND BRYAN L. ROTH 1 Departments of Biochemistry (Q.S., B.L.R.), Genetics (Q.S., J.H.N.), and Nutrition (P.E.), National Institute of Mental Health Psychoactive Drug Screening Program (J.E.S., S.J.H., L.R., B.L.R.), School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106; Department of Pharmacology (J.T.W., E.G), Georgetown University Medical Center, 3900 Reservoir Road, N.W., Washington, D.C. 20007 Copyright 2003 by the American Society for Pharmacology and Experimental Therapeutics. JPET Fast Forward. Published on January 21, 2003 as DOI:10.1124/jpet.102.047092 This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on January 21, 2003 as DOI: 10.1124/jpet.102.047092 at ASPET Journals on November 28, 2021 jpet.aspetjournals.org Downloaded from