International Journal of Advanced Engineering Research and Science (IJAERS) Peer-Reviewed Journal ISSN: 2349-6495(P) | 2456-1908(O) Vol-10, Issue-3; Mar, 2023 Journal Home Page Available: https://ijaers.com/ Article DOI: https://dx.doi.org/10.22161/ijaers.103.5 www.ijaers.com Page | 44 Study evaluating the ability of Fe-BDC-PEG to carry and release active ingredient 5-fluorouracil Thu Hanh Pham Thi, Hoai Phuong Nguyen Thi Institute of Chemistry and Materials, Hanoi, VIETNAM *Email: hoaiphuong1978@gmail.com Received: 15 Jan 2023 Received in revised form: 8 Mar 2023 Accepted: 13 Mar 2023 Available online: 19 Mar 2023 ©2021 The Author(s). Published by AI Publication. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). Keywords— Metal-organic framework, 5 Fluorouracil, drug carrier, ultrasonic method. Abstract— This paper presents the results of 5 fluorouracil carrying- release of iron (III) framework materials with two ligands of 1,4-benzene dicarboxylic acid and polyethylene glycol diacid synthesized by ultrasonic bath method at room temperature. Materials were characterized, and their properties by scanning electron microscopy (SEM) and infrared spectroscopy (FT-IR) techniques showed that the active ingredient was fully adsorbed into the structural framework of the material without changing the shape and size of the material. The evaluation results for the 5-fluorouracil carrying capacity of Fe-BDC-PEG two-ligand Fe-BDC- PEG framework material showed that the drug absorption capacity reached 358.707 mg/g. The slow-release characteristics of the material were also evaluated, indicating that the effective release of the active ingredient came to 94.42% after 7 days, and the maximum after 10 days reached 97.68%. The Fe-BDC-PEG@5-FU drug carrier material system is studied to orient the application of cancer treatment when minimizing side effects based on the slow release of the system. I. INTRODUCTION Metal-organic framework materials (MOFs) are the self- assembly of metal ions as coordination centre and organic ligands as bridges between metal centre [1]. Currently, MOFs have been attracting attention because of their potential applications. In particular, iron(III)-organic framework materials, with advantages such as pore size and large surface area, low toxicity... [2], have been applied in many fields such as catalysis, 3], adsorption [4], sensing [5] and biomedicine [6]. Many methods have been used to synthesize iron(III)-organic framework materials such as hydrothermal, microwave, ultrasonic [6-8] … 5-fluorouracil is a widely used antineoplastic drug treating many malignancies [9]. The mechanism of action of this drug is based on the irreversible inhibition of the enzyme thymidylate synthase and, at the same time, induces incorrect synthesis in cancer cells belonging to the group of anti-metabolites. However, it has the disadvantage of a short half-life and low stability in the biological environment [10], which requires an efficient drug delivery-carrying system to overcome. One of the potential applications of iron(III)-organic framework materials is in drug conduction-carrying-drug delivery due to their biocompatibility and ability to absorb large amounts of drugs. Its capability has been demonstrated with many drugs such as busulfan, doxorubicin, ibuprofen, aspirin, etc. [11-14] This paper presents research results on the 5-fluorouracil carrying and releasing capacity of iron(III)-organic framework materials with a mixture of 2 ligands, 1,4- benzene dicarboxylic acid (H2BDC) and polyethylene glycol di-acid synthesized by ultrasonic technique at room temperature, orienting its application in cancer treatment. II. EXPERIMENTS - Chemicals: Polyethylene glycol 250 di-acid, 1,4-benzene dicarboxylic, iron (III) chloride, dimethyl-formamide,