ISPUB.COM The Internet Journal of Third World Medicine Volume 5 Number 2 1 of 5 Primary Tubercular Osteomyelitis Of The Sternum: Report of Two cases S Bajracharya, G Singh, M Singh Citation S Bajracharya, G Singh, M Singh. Primary Tubercular Osteomyelitis Of The Sternum: Report of Two cases. The Internet Journal of Third World Medicine. 2006 Volume 5 Number 2. Abstract Tubercular involvement of the sternum, leading to osteomyelitis, is a rarely described entity even in countries where tuberculosis is endemic. Frank Presentation of this entity is even more uncommon. We describe two cases who presented with discharging sinuses with erythematous lesion over the sternum with constitutional symptoms like fever, loss of appetite and significant weight loss, but without features of pulmonary tuberculosis like cough, hemoptysis. Plain Radiographs demonstrated eroding cortex of the manubrium with lytic lesion. Tubercular etiology was suggested by presence of epithelioid granulomas and acid fast bacilli in the Ziehl-Neelsen staining of the aspirate from the lesion. Both patients responded well to antitubercular treatment. INTRODUCTION Tuberculosis remains a formidable challenge to health care providers in developing countries. Sternal osteomyelitis is a rarely described manifestation of tuberculosis. We report an unusual cases of sternal tubercular osteomyelitis treated with Anti tubercular regimen of 12 months duration. CASE 1 A 35-year-old male, from Sarlahi, a Terai district of Eastern Nepal, presented with complaints of a discharging sinus with redness on the anterior chest wall, over the manubrium, noticed to be present over the last 3 months. He also had low grade fever, with evening rise, and anorexia of 3 months duration. There was no history of cough, expectoration or chest pain; and no significant family history. On examination, he was afebrile, weighed 50 kg. A 4 X 4 cm erythematous lesion with discharging sinus was present over the distal part of the sternum and another discharging sinus just distal and right part of anterior chest wall as shown in Fig 1 (a). There was no significant lymphadenopathy. Systemic examination revealed no abnormalities. Investigations revealed a decreased hematocrit and lymphocytosis. The ESR was elevated at 48mm/hr. Chest X- ray PA view was normal, however the lateral film revealed cortical breach and irregularity of the xiphisternum along with a lytic lesion as shown in Fig 1 (b). Contrast enhanced computed tomography (CT) of the chest was advised, but deferred because of ecomomic problems of patient. Ultrasonography of the abdomen was normal. The fine needle aspiration cytology (FNAC) from the affected area revealed numerous epithelioid cell granulomas with mononuclear infiltrate and scattered giant cells. Ziehl- Neelsen staining of the aspirate was positive for acid fast bacilli. HIV serology was negative. The patient was started on antitubercular treatment with four drugs: isoniazid, rifampicin, ethambutol and pyrazinamide. After 2 weeks of the treatment, his appetite improved with decrease in discharge. After 1 months of treatment, the erythema had subsided, and the patient had also gained weight. After 3 months of treatment, discharging sinus was healed completely. He was switched over to continuation phase with 3 drugs: isoniazid, rifampicin and pyrazinamide which were continued for another 9 months. The patient was completely cured with total 12 months of Antitubercular drugs.