Accepted Article Cross-resistance risk of the novel complex II inhibitors cyenopyrafen and cyflumetofen in resistant strains of the two-spotted spider mite Tetranychus urticae. Mousaalreza Khalighi a , Luc Tirry a and Thomas Van Leeuwen a* a Department of Crop Protection, Faculty of Bio-science Engineering, Ghent University, Coupure links 653 B-9000 Ghent, Belgium *Correspondence to: Thomas.vanleeuwen@ugent.be ABSTRACT BACKGROUND Cyflumetofen and cyenopyrafen are novel acaricides acting as complex II inhibitors. This new mode of action is extremely useful for devising efficient resistance management strategies for mite control. We determined the cross-resistance risk of both compounds using a collection of well-characterized resistant strains of Tetranychus urticae, and also selected for cyflumetofen resistance in the laboratory. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ps.3641 This article is protected by copyright. All rights reserved.