Int. J. Pharm. Sci. Rev. Res., 73(2), March - April 2022; Article No. 32, Pages: 178-183 ISSN 0976 – 044X International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net ©Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 178 Nidhi Kumari 1 , Sarita Kumari Mishra 2 , Manish Kumar 3 , Adil Ali Shakur* 4 , Hitesh Mishra 5 , Harihar Dikshit 6 1. Junior Resident, Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. 2. Additional Professor, Department of ENT, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. 3. Additional Professor, Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. 4. Assistant Professor, Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. 5. Additional Professor, Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. 6. Professor and Head, Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. *Corresponding author’s E-mail: adilshakur04@gmail.com Received: 18-01-2022; Revised: 26-03-2022; Accepted: 05-04-2022; Published on: 15-04-2022. ABSTRACT Diseases related to Ear, Nose & Throat (ENT) occur very commonly in all age groups. Thus periodic evaluation of prescription pattern and adverse drug reaction (ADR) monitoring will be helpful in enabling appropriate modifications in prescribing pattern. This will also result in improved therapeutic efficacy and better patient compliance. The aim of the study is to evaluate prescription pattern of drugs prescribed in ENT OPD and to analyse the ADRs from ENT Department (IPD & OPD). This was an observational & prospective study, conducted for the duration of six months i.e. from March 2021 to October 2021. Prescription was analysed for demographic details, pattern of prescribed medications, pattern/types of ENT diseases and adequacy of prescription. For monitoring of ADRs active surveillance and spontaneous reporting both were used. In this study, prescription of 251 patients were analysed. It was found that male patients (64.5%) were significantly higher. A total of 850 drugs were prescribed. The most commonly prescribed group of drugs were antimicrobials. Most commonly prescribed FDC was of cefpodoxime and clavulanic acid. Otitis media was the most commonly suffered condition. Dose, frequency, total duration of treatment and instructions in vernacular language was mentioned in all the prescription. The average number of drugs prescribed was 3.3. A total of four ADRs were reported. This study was a sincere attempt to see the prescribing pattern of drugs prescribed in ENT department and its associated ADRs. Antimicrobials were the most commonly prescribed drugs and it could be attributed to increased occurrence of infections. The adequacy of prescription demonstrates good aspects of prescription writing. Since no prescription had more than five drugs; we can say that polypharmacy was avoided. ADR reporting was very low so it strongly suggests the need to spread awareness among health-care workers and patients for reporting. Keywords: Adverse drug reaction, Antimicrobials, ENT, Prescription pattern. QUICK RESPONSE CODE → DOI: 10.47583/ijpsrr.2022.v73i02.032 DOI link: http://dx.doi.org/10.47583/ijpsrr.2022.v73i02.032 INTRODUCTION iseases related to Ear, Nose & Throat (ENT) occur very commonly in both paediatric as well as adult age groups often leading to significant impairment of accustomed daily pursuits in adult age groups which might lead to work loss and wage loss in them as well as absenteeism from schools in children. This often hampers their academics and normal routine activities. Some of the routinely encountered problems includes upper respiratory tract infection (URTI), otitis media, impacted ear wax, unilateral and bilateral hearing loss of conductive or sensorineural type. 1 URTI commonly includes common cold, pharyngitis, epiglottitis, laryngotracheitis and associated etiologic agents include viruses, bacteria, mycoplasma and fungi. However, overall there is preponderance of RTI which occur mostly due to viruses and these viral infections are usually benign, transitory, self-resolving and require only symptomatic management with no requirement of adding any antibiotics unless and until it is associated with secondary bacterial infections amounting to otitis media, epiglottitis, laryngotracheitis etc. 2-4 However, often indiscriminate and irrational use of antibiotics leads to bacterial resistance, ineffective treatment, economic burden on patients and also adverse drug reactions (ADRs). 5 The analysis of prescription pattern plays an important role in clinical practice as it forms the basis for making changes in the drug dispensing policies at local and national levels. The end objective of such study is to facilitate rational use of drugs. As this type of study helps in developing strategies to utilize health resources in the appropriate manner, it is particularly needed in a developing countries like India where 72% of all health care burden is borne by the patients. 6 World Health Organization defines drug use as ‘The marketing, distribution, prescribing and usage of drug in society, with special emphasis on medical, social and economical consequences. 7 Therefore, it becomes Prescription Pattern of Drugs Prescribed in Out Patient Department of ENT and Adverse Drug Reactions Reported from ENT Department in A Tertiary Care Hospital of Bihar D Research Article