S1
OrganocatalyticAsymmetricMannich reaction for the Synthesis of
3,3-Disubstituted 3,4-Dihydro-2-quinolones
Soumendranath Mukhopadhyay and Subhas Chandra Pan*
Department of Chemistry, IIT Guwahati, North Guwahati, Assam, 781039
Table of contents
A. General information……………………………………………………….…S2
B. General procedure for the synthesis of compound 3…………………………S3
C. Optimization table for amidosulfones…………………………………………S3-S4
D. General procedure for the synthesis 3a with preformed N-Boc imines………......S5
E. Crystal structure of compound 3v………………………………………………..S5-S6
F. Characterization data for compounds (3a-3y)……………………………………S6-S18
G. General procedure and the characterization data of compound 5……………...S18-S19
H. General procedure and the characterization data of compound 6…………..….S19-S20
I. References…………………………………………………………………….......S20
J. NMR spectra for compounds (3a-3y)......................................................................S21-S44
K. NMR spectra for compounds 5 and 6......................................................................S45-S46
L. HPLC chromatograms for compounds (3a-3y)………………..............................S47-S70
M. HPLC chromatograms for compounds 5 and 6…...................................................S71-S72
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.
This journal is © The Royal Society of Chemistry 2018