Diabetes & Metabolism 36 (2010) 443–449 Original article Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients M.Y. Gharibeh a,∗ , G.M. Al Tawallbeh a , M.M. Abboud b , A. Radaideh c , A.A. Alhader d , O.F. Khabour a a Department of Medical Laboratory Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan b Department of Biochemistry, Muta’ University, Muta’, Jordan c Princess’ Basma Teaching Hospital, Irbid 22110, Jordan d Department of Physiology, Jordan University of Science and Technology, Irbid 22110, Jordan Received 4 March 2010; received in revised form 20 May 2010; accepted 26 May 2010 Available online 23 August 2010 Abstract Aim. – The aim of this case-control study was to assess the relationship between resistin levels and obesity and insulin resistance in type 2 diabetic patients. Methods. – The study involved a sample of the Jordanian population that included 140 type 2 diabetic patients and 125 control subjects. Results. – Serum resistin levels were higher in type 2 diabetic patients compared with the controls (P < 0.01). Markers of adiposity [body mass index (BMI) and waist circumference (WC)] and insulin resistance, as well as fasting blood glucose, glycated haemoglobin, urea and blood pressure were considerably higher among the studied diabetics than in the controls. When diabetic patients were subdivided into age-group categories of 10-year intervals, resistin levels significantly increased with increased age, with a significant proportion in the group aged > 60 years (P < 0.01). Similarly, there was a significant association between plasma resistin and blood urea with growing older in diabetic patients. Pearson’s analysis revealed positive correlations between plasma resistin and age, urea, creatinine, insulin, BMI, WC, body-fat content and homoeostasis model assessment (HOMA). Furthermore, plasma resistin concentrations were higher in type 2 diabetic obese patients than in non-diabetic obese subjects (P < 0.01), whereas no such difference was found between overweight and normal-weight controls. Conclusion. – These results suggest that variations in resistin concentrations are not directly related to susceptibility to type 2 diabetes. However, it may be that resistin plays a role in the pathogenesis of obesity and insulin resistance, both of which could, indirectly, contribute to the development of type 2 diabetes. © 2010 Elsevier Masson SAS. All rights reserved. Keywords: Resistin; Type 2 diabetes; Obesity; Insulin resistance; Jordan Résumé Corrélation des concentrations plasmatiques de résistine avec l’obésité et l’insulinorésistance chez des diabétique de type 2. But. – Évaluer les relations entre concentrations plasmatiques de résistine, obésité et insulinorésistance dans le diabète de type 2 (DT2). Méthodes. – Une étude cas-témoins a été réalisée à partir d’un échantillon de la population jordanienne qui comprenait 140 patients atteints de DT2 et 125 témoins. Résultats. – Les concentrations plasmatiques de résistine étaient plus élevées chez les DT2 que celles des témoins (P < 0,01). Les marqueurs d’adiposité (indice de masse corporelle et tour de taille), d’insulinorésistance, la glycémie à jeun, l’HbA 1c , l’urée et la pression artérielle étaient plus Abbreviations: BMI, Body mass index; DBP, Diastolic blood pressure; FPG, Fasting plasma glucose; HbA 1c , Haemoglobin A 1c ; HIS, Hepatic insulin sensitivity; HOMA, Pancreatic -cell secretory capacity; IR, Insulin resistance; LBM, Lean body mass; SBP, Systolic blood pressure; TC, total cholesterol; TR, Triglycerides. ∗ Corresponding author. Tel.: +962 2 7201000 ext 23772; fax: +962 2 7201087. E-mail address: younisgh@just.edu.jo (M.Y. Gharibeh). 1262-3636/$ – see front matter © 2010 Elsevier Masson SAS. All rights reserved. doi:10.1016/j.diabet.2010.05.003 © 2021 Elsevier Masson SAS. Tous droits réservés. - Document téléchargé le 05/12/2021 Il est interdit et illégal de diffuser ce document.