Vol.: (0123456789) 1 3 Cell Tissue Bank https://doi.org/10.1007/s10561-022-10062-0 MINI REVIEW Regenerative medicine improve neurodegenerative diseases Seyedeh Sara Ashraf · Vahid Hosseinpour Sarmadi · Ghazaleh Larijani · Soheila Naderi Garahgheshlagh · Sara Ramezani · Soraya Moghadamifar · Seyedeh Lena Mohebi · Peiman Brouki Milan · Seyed Mohammad Amin Haramshahi · Nooshin Ahmadirad  · Naser Amini Received: 30 April 2022 / Accepted: 4 December 2022 © The Author(s), under exclusive licence to Springer Nature B.V. 2022 Abstract Regenerative medicine is a subdivision of medicine that improves methods to regrow, repair or replace unhealthy cells and tissues to return to normal function. Cell therapy, gene therapy, nanomedicine as choices used to cure neurodegenerative disease. Recently, studies related to the treatment of neurode- generative disorders have been focused on stem cell therapy and Nano-drugs beyond other than regen- erative medicine. Hence, by data from experimental models and clinical trials, we review the impact of stem cell therapy, gene therapy, and nanomedicine on the treatment of Alzheimer’s disease (AD), Parkin- son’s disease (PD), and Amyotrophic lateral sclerosis (ALS). Indeed, improved knowledge and continued research on gene therapy and nanomedicine in treat- ing Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis lead to advancements in efective and practical treatments for neurodegenera- tive diseases. S. S. Ashraf · G. Larijani  Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran S. S. Ashraf · V. Hosseinpour Sarmadi · G. Larijani · S. L. Mohebi · N. Ahmadirad (*) · N. Amini (*)  Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran e-mail: ahmadiyerad@gmail.com N. Amini  e-mail: amini_ot@yahoo.com S. S. Ashraf · V. Hosseinpour Sarmadi · S. L. Mohebi · P. Brouki Milan · N. Amini  Institutes of Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran V. Hosseinpour Sarmadi · P. Brouki Milan · S. M. A. Haramshahi  Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran S. Naderi Garahgheshlagh  Burn Research Center, Iran University of Medical Sciences, Tehran, Iran S. Naderi Garahgheshlagh · S. M. A. Haramshahi  Department of Plastic and Reconstructive surgery, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran S. Ramezani  Neuroscience Research Center, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran S. Ramezani  Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran S. Moghadamifar  Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran