Journal of Alzheimer’s Disease 67 (2019) 685–705 DOI 10.3233/JAD-180341 IOS Press 685 Two Year Outcomes, Cognitive and Behavioral Markers of Decline in Healthy, Cognitively Normal Older Persons with Global Deterioration Scale Stage 2 (Subjective Cognitive Decline with Impairment) Barry Reisberg a,f ,n,o,∗ , Carol Torossian a , Melanie B. Shulman a,b , Isabel Monteiro a , Istvan Boksay a , James Golomb a,b , Francoise Guillo Benarous a,b , Anaztasia Ulysse b , Thet Oo b , Alok Vedvyas b , Julia A. Rao b , Karyn Marsh b , Alan Kluger a,g , Jaspreet Sangha a , Mudasar Hassan a , Munther Alshalabi a , Fauzia Arain a , Naveed Shaikh h , Maja Buj a , Sunnie Kenowsky a , Arjun V. Masurkar b , Laura Rabin i,o , Maryam Noroozian j,n , Mar´ ıa Bel´ en S´ anchez-Saudin´ os k,l , Rafael Blesa k,l,n , Stefanie Auer m , Yian Zhang e , Mony de Leon a , Martin Sadowski a,b,c , Thomas Wisniewski a,b,d , Serge Gauthier f ,n and Yongzhao Shao e a Department of Psychiatry, New York University Langone Health, New York, NY, USA b Department of Neurology, New York University Langone Health, New York, NY, USA c Departments of Biochemistry and Molecular Pharmacology, New York University Langone Health, New York, NY, USA d Department of Pathology, New York University Langone Health, New York, NY, USA e Division of Biostatistics, Department of Population Health and Department of Environmental Medicine, New York University Langone Health, New York, NY, USA f Departments of Neurology & Neurosurgery, Psychiatry, and Medicine, McGill University Research Centre for Studies in Aging, Qu´ ebec, Canada g Department of Psychology, Lehman College, City University of New York, New York, NY, USA h Kings County Hospital Center, New York, NY, USA i Department of Psychology, Brooklyn College and The Graduate Center, City University of New York, New York, NY, USA j Memory and Behavioral Neurology Division, Roozbeh Hospital, Department of Psychiatry, Tehran University Medical Sciences, Tehran, Iran k Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain ∗ Correspondence to: Barry Reisberg, MD, Professor, Depart- ment of Psychiatry, Aging & Dementia Clinical Research Center, NYU Alzheimer’s Disease Center, New York University Langone Health, 145 East 32nd Street, Room 508, New York, NY 10016, USA. Tel.: +1 212 263 8550; Fax: +1 212 263 6991; E-mail: barry.reisberg@nyulangone.org. ISSN 1387-2877/19/$35.00 © 2019 – IOS Press and the authors. All rights reserved