COLLAGEN SPHERULOSIS : A RARE INCIDENTAL FINDING IN PROLIFERATIVE BREAST LESIONS DR. A. N. PANDYA (Asst. Prof); DR. HIREN DHANANI (Tutor); DR. JIGAR MEHTA (3rd Year Resident) Dept. of Pathology, Medical College, Surat, Gujarat. April 2006 INTRODUCTION: Collagen spherulosis is an unusual, incidental finding in proliferative breast lesion which is characterized by collagen rich spherules made up of basement membrane material. It can be associated with other benign proliferative breast lesion. Carcinoma may be present coincidently, but they are neither associated with malignancy nor they are precancerous. CASE DETAIL: We came across a case of 35 year old female, who noticed swelling in right breast since 15 days. Occasional pain was there. Menstrual and obstetric history was not significant. Lump was 1 x 1 cm in diameter, well defined, firm, nontender and mobile. Smears yielded high cellularity, showing ductal epithelial cells in sheets and groups. Cells showed mild to moderate degree of anisonucleosis and pleomorphism, moderate amount of cytoplasm, occasional nuclear overlapping and bland nuclear chromatin. Background showed bipolar-bare nuclei, myoepithelial cells, stromal fragments and hyaline globules surrounded by cells.(Score 11). She was stamped as having 'Proliferative breast lesion without atypia with collagen spherulosis.'