Research 10.4172/Neuropsychiatry.1000542 © 2018 p- ISSN 1758-2008 e- ISSN 1758-2016 Neuropsychiatry (London) (2018) 8(6), 1993–1997 1993 Cerebral Blood Flow, White Matter Micro-Structures and Gray Matter Function in Adult Aged 61-81 Years Katarzyna Porzych 1 , Zbigniew Serafn 2 , Elżbieta Zawada 2,3 , Emilia Mikolajewska 4,5 , Dariusz Mikolajewski 5,6 , Martyna Porzych 7 , Zofa Skubisz 8 , Daria Kupczyk 9† , Beata Augustynska 10 1 Multidisciplinary Clinic ‘Bartodzieje’ Bydgoszcz, Poland 2 Department of Radiology and Medical Imaging, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland 3 Department and Clinic of Geriatrics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus University, Toruń, Poland 4 Department of Physiotherapy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland 5 Neurocognitive Laboratory, Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, Toruń, Poland 6 Institute of Mechanics and Applied Computer Science, Kazimierz Wielki University, Bydgoszcz, Poland 7 Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland 8 Ludwik Warmiński Municipal Hospital in Bydgoszcz, Poland 9 Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland 10 Institute of Physical Education, Kazimierz Wielki University in Bydgoszcz, Poland † Author for correspondence: Daria Kupczyk, Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland, email: dariak@cm.umk.pl ABSTRACT Background Aim of this study was assess cerebral blood fow, white matter micro-structures and gray matter function, and biochemical correlates of oxidative stress in adult aged 61-81 years. Patients and methods The study included a total of 50 patients aged from 61 to 81 years. All patients underwent arterial spin labeling (ASL), difusion tensor imaging (DTI) and biochemical analysis of venous blood concerning values of the selected parameters of oxidative stress. Results and discussion Statistically signifcant correlations between ASL and DTI results were observed, but none correlations between ASL, DTI and biochemical markers of oxidative stress were observed, despite showed reduced efectiveness of the body’s natural antioxidant barrier in elderly people. Conclusions This study may be regarded preliminary to bigger comparative research. Factors infuencing successful prevention of changes and strengthening the defense system may be a direction of further research. Keywords Aging, Antioxidant barrier, Cognitive changes, Biochemical changes, Medical imaging