mrj.ub.ac.id| Vol 04(01) page 192 Mediastinal Lymphohemangioma (Case Report): a Rare Case Report of Difficult Diagnosis Fitratul Ramadhan 1 , Suryanti Dwi Pratiwi 1 , Artono Isharanto 2 , Dini Rachma Erawati 3 , Hendy Setyo Yudhanto 4 1 Department of Pulmonology and Respiratory Medicine, Medical Faculty, University of Brawijaya, RSUD Dr. Saiful Anwar Malang 2 Department of Thoracic and Cardiovascular Surgery, Medical Faculty, University of Brawijaya,, Malang, Indonesia 3 Department of Radiology, Medical Faculty, University of Brawijaya,, Malang, Indonesia 4 Department of Pathological Anatomy, Medical Faculty, University of Brawijaya,, Malang, Indonesia Abstract Introduction: Mediastinal lymphohemangioma is a very rare, benign, congenital malformation. Mediastinal lymphohemangioma originates from local proliferation of lymphatic vessels. Case: This disorder is accountable for 4.5% among all mediastinal tumors. Most lymphohemangiomas are found in the neck and axillary region among children, whereas only 1% are found in the mediastinum and tend to occur in individuals aged over 20 years old. A proper understanding is needed to be able to make a diagnosis and perform effective management of mediastinal lymphohemangioma Conclusion: In this case report, a woman with a diagnosis of mediastinal lymphohemangioma, established through a multidisciplinary approach covering the fields of pulmonology, thoracic and cardiovascular surgery, radiology, and anatomical pathology. Keywords: Mediastinal Lymphohemangioma, Core Biopsy, Thoracotomy MRJ 2022; 4(1):192-200 1. Background Tumors in the mediastinal cavity could manifest as either benign or malignant, each with different management and prognosis. The occurrence of tumors in the mediastinal cavity are relatively rare, but the frequency and prev- alence of malignant lesions tends to increase. Overall, the prevalence of mediastinal tumors in adults is 1%. Mediastinal tumors can be ei- ther primary or secondary tumors. Primary tu- mors are tumors originating from tissues/or- * Corresponding author: Fitratul Ramadhan (fitdoudompu.fr@gmail.com) Department of Pulmonology and Respiratory Medicine, Medical Faculty, University of Brawijaya, RSUD Dr. Saiful Anwar Malang Jl. Jaksa Agung Suprapto No. 2, Malang, Indonesia – 65111 gans in the mediastinum such as; thymus, neu- rogenic, germ cells, mesenchymal tissue. Sec- ondary tumors are usually more frequent than primary tumors, and commonly spread through the lymphatic system from the lungs or infra- diaphragm organs such as the pancreas, gas- troesophageal and testicular. 1 Mediastinal tumors mostly occur within the 3rd to 5th decade of age. The incidence of anterior, middle, and mediastinal tumors were 54%, 20% and 26% respectively. 2 In adults, the most common types of mediastinal tumors