1 An Innovative Non-Hormonal Strategy Targeting Redox Active Metals to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer Faten Shehadeh-Tout, 1,2 Heloisa H. Milioli, 3 Suraya Roslan, 4 Patric J. Jansson, 5 Mahendiran Dharmasivam, 6 Dinny Graham, 7 Robin Anderson, 4,8 Tharushi Wijesinghe, 6 Mahan Gholam Azad, 6 Des R. Richardson, 6,9* and Zaklina Kovacevic. 1,10* 1 School of Medical Sciences, University of Sydney, NSW 2006, Australia 2 Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, Zarqa 13133, Jordan 3 Connie Johnson Breast Cancer Research Laboratory, Garvan Institute of Medical Research, NSW 2010 Australia. 4 Metastasis Research Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg Vic 3084, Australia. 5 Cancer Drug Resistance and Stem Cell Program, School of Medical Sciences, University of Sydney, NSW 2006, Australia. 6 Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, 4111, Queensland, Australia. 7 Breast Cancer Group, The Westmead Institute for Medical Research and Westmead Clinical School, University of Sydney, NSW 2145 Australia. 8 School of Cancer Medicine, La Trobe University, Bundoora, 3086, Victoria, Australia. 9 Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. 10 Department of Physiology, School of Biomedical Sciences, University of NSW, NSW 2052 Australia. * Authors for Correspondence (Contribution as Equal Senior Corresponding Authors): Dr. Zaklina Kovacevic, Department of Physiology, School of Biomedical Sciences, University of NSW, NSW 2052 Australia. Email: z.kovacevic@unsw.edu.au. Dr. Des R. Richardson, Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, 4111, Queensland, Australia. Email: d.richardson@griffith.edu.au. (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint this version posted February 3, 2023. ; https://doi.org/10.1101/2023.02.02.526543 doi: bioRxiv preprint