S1 | Page Resveratrol’s Hidden Hand: A Route to Optical Detection of Biomolecular Binding Subhojyoti Chatterjee 1 , Seth Olsen 1,2# , Ewan W. Blanch 3 and Feng Wang 1,4,5* 1 Molecular Model Discovery Laboratory, Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Melbourne, PO Box 218, Victoria, 3122, Australia 2 School of Mathematics and Physics, The University of Queensland, Brisbane QLD 4072 Australia 3 School of Science, RMIT University, Melbourne, VIC 3001, Australia 4 School of Chemistry, University of Melbourne, Parkville, Victoria 3052, Australia, 5 School of Physics, University of Melbourne, Parkville, Victoria 3052, Australia Corresponding author : * Feng Wang, E:mail addresses fwang@swin.edu.au; Tel: +61 3 9214 5056; fax: +61:3:9214:5921; # Seth Olsen solsen@swin.edu.au. This article is in memory of our colleague and friend, Dr Seth Olsen who passed away in 2018. Supporting Information Experimental HPLC and FTIR method…………………………………………………………….S3 Figure S1: Experimental (red) and simulated (black) Raman scattering (left) and infrared absorbance (right) spectra of E:resveratrol in the organic “fingerprint” region 250:1750 cm :1 . Experimental spectra were taken from Billes et al., 2007. Calculated mode frequencies were scaled by a factor of 0.98, and the resulting line spectra convolved using a Lorentzian distribution with 4cm :1 FWHM. Measured and simulated spectra were normalized by to their respective maxima. Experimental spectra were taken in solid state (Raman) and KBr pellet (IR); simulations were taken for the isolated molecule in vacuum………………………………………………………………………………………………...S5 Figure S2: HPLC chromatography of (a) E – resveratrol sample (b) wine sample (c) E – resveratrol (98% purity) before exposing to UV radiation and (d) E – resveratrol (98% purity) after exposing to 316nm UV radiation for ~20 hours………………………………………………………………….....S6