JPET#98970 1 Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to ICAM-1 Silvia Muro, Thomas Dziubla, Weining Qiu, John Leferovich, Xiumin Cui, Erik Berk, and Vladimir R. Muzykantov Institute for Environmental Medicine (SM, TD, WQ, JL, XC, EB, VM), Targeted Therapeutics Program of the Institute for Translational Medicine and Therapeutics (SM, TD, VM), Department of Pharmacology (SM, VM), School of Medicine; Department of Bioengineering (WQ), School of Engineering and Applied Sciences, University of Pennsylvania JPET Fast Forward. Published on February 27, 2006 as DOI:10.1124/jpet.105.098970 Copyright 2006 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on February 27, 2006 as DOI: 10.1124/jpet.105.098970 at ASPET Journals on January 24, 2022 jpet.aspetjournals.org Downloaded from