ORIGINAL RESEARCH ARTICLE J of Evidence Based Med &Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 1/ Issue 7 / Sept. 2014. Page 794 STUDY OF LIPID PROFILE IN NEWLY DIAGNOSED HIV POSITIVE PATIENTS IN CORRELATION WITH CD4+COUNT Rakesh Kumar 1 , Vishal Parmar 2 , Pramod Kumar Agrawal 3 , Mehre Darakhshan Mehdi 4 , Nasar Reza 5 HOW TO CITE THIS ARTICLE: Rakesh Kumar, Vishal Parmar, Pramod Kumar Agrawal, Mehre Darakhshan Mehdi, Nasar Reza. “Study of Lipid Profile in Newly Diagnosed HIV Positive Patients in Correlation with CD4+Count”. Journal of Evidence Based Medicine and Healthcare; Volume 1, Issue 7, September 2014; Page: 794-801. ABSTRACT: Human Immunodeficiency Virus (HIV) is the causative agent for Acquired Immuno Deficiency Syndrome (AIDS). AIDS is a fatal illness which burns down the body’s immune system making the victim vulnerable to multiple life threatening opportunistic infections, neurological disorders or unusual malignancies. A variety of endocrinologic, metabolic and nutritional disturbances are common during the course of HIV infection. Most HIV infected patients develop multiple metabolic abnormalities including insulin resistance, lipodystrophy and dyslipidaemia. An observation on the nature of dyslipidaemia in HIV positive patients with reference to correlation if any that exists between CD4+ levels and lipid profile in these patients was performed. Results revealed that the total cholesterol, HDL and LDL decreased while triglycerides and VLDL were found to increase as CD4+ levels depleted. It can be concluded that changes in lipid profile can be a good index of disease progression in HIV infection. KEYWORDS: Lipid profile, HIV, CD4+. INTRODUCTION: AIDS is a fatal illness caused by a retrovirus known as the Human Immunodeficiency Virus (HIV) which breaks down the body’s immune system, leaving the victim vulnerable to a host of life threatening opportunistic infections, neurological disorders, or unusual malignancies.¹ India is estimated to have around 1.6 lakh annual new HIV infections among adults and around 14,500 new HIV infections among children in 2011. OF the 1.16 lakh estimated new infections in 2011 among adults, the previously high HIV prevalence States of Andhra Pradesh, Karnataka, Maharashtra ,Tamil Nadu, Manipur and Nagaland account for 31% of new infections, where some low prevalence states (Odisha, Jharkhand, Bihar, Uttar Pradesh, West Bengal, Gujarat, Chhattisgarh, Rajasthan, Punjab and Uttarakhand) together account for around 57% of new infections.² AIDS is affecting mainly the young people in sexually active age group. The majority are infected through unprotected sex. Impoverished, unemployment under employed, mobile, and migrant youth, and street children are also particularly vulnerable to HIV or access to preventive measures, and they may face repeated risks of HIV infection. The immune system disorders associated with HIV infection/AIDS are considered to occur primarily from the gradual depletion in a specialized group of white blood cells (lymphocytes) called T-Helper or T-4 cells. The full name of T-Helper cells is CD4+ T lymphocyte and is commonly known as CD4+ cell. These cells play a key role in regulating the immune response. HIV selectively infects T-Helper cells apart from several other cells. When the virus reproduces, the infected T-Helper cells are destroyed. Consequently people with AIDS tend to have low overall white blood cell count.³ A variety of endocrinologic, metabolic and nutritional disturbances are common during the course of HIV infection. Most HIV-infected