Research rticle
Association of Anemia with Parathyroid Hormone Levels and
Other Factors in Patients with End-Stage Renal Disease
Undergoing Hemodialysis: A Cross-Sectional, Real-World Data
Study in Pakistan
Humera Bukhari,
1
Aneeqa Ahmad,
2
Amna Noorin,
3
Aimal Khan,
4
Mehwish Mushtaq ,
5
Aamir Naeem,
6
Muhammad Rashid Iqbal,
7
Faiza Naureen,
8
Yasar Shah,
8
Ahad Qayyum,
9
Syed Munib,
10
Amer Azhar,
11
Farman Ullah,
11
and Faris Farooq Saeed Khan
12
1
Nephrology Ward, Jinnah Teaching Hospital, Khyber Pakhtunkhwa, Peshawar, Pakistan
2
District Headquarters DHQ Hospital, Faisalabad, Punjab, Pakistan
3
Peshawar Institute of Cardiology •M.T. I, Khyber Pakhtunkhwa, Peshawar, Pakistan
4
Northwest General Hospital and Research Center, Khyber Pakhtunkhwa, Peshawar, Pakistan
5
Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Peshawar, Pakistan
6
Consultant Physician in Endocrinology, Madinat Zayed Hospital SEH bu Dhabi Health Services, bu•Dhabi, UE
7
Consultant Physician in Medicine, University Hospital Birmingham, UK
8
Department of Pharmacy, bdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan
9
Nephrology Ward, Bahria International Hospital, Lahore, Pakistan
10
Nephrology Ward, Institute of Kidney Disease Hayatabad Peshawar, Khyber Pakhtunkhwa, Peshawar, Pakistan
11
Nephrology Ward, Khyber Teaching Hospital M. T. I., Khyber Pakhtunkhwa, Peshawar, Pakistan
12
Department of Community Health Sciences, ga Khan University, Karachi, Pakistan
CorrespondenceshouldbeaddressedtoMehwishMushtaq;mahmushtaq@gmail.com
Received 7 October 2022; Revised 12 December 2022; Accepted 9 January 2023; Published 13 February 2023
AcademicEditor:B.D.Parameshachari
Copyright © 2023 Humera Bukhari et al. Tis is an open access article distributed under the Creative Commons Attribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
End•stage renal disease (ESRD) patients are mostly managed with maintenance hemodialysis (MHD). ESRD patients on MHD
alsopresentwithmanycomplications,suchasanemia,hyperparathyroidism,andhepatitisprevalence.Tisstudydepictsthereal•
world scenario of anemia among MHD and end•stage renal disease patients in the Pakistani population. A retrospective,
multicentric,andreal•worlddataanalyticalstudywasconductedat4dialysiscentersinPakistan.Testudyhadasamplesizeof
n =342 patients on maintenance hemodialysis. Te data were gathered from the medical records of patients. Data analysis was
performedusingSTATAVersion16.Statisticalsignifcancewasgaugedata0.05levelofsignifcance.Accordingtoourresults,the
meanageofthepatientswas45(±15)years.Mostofthepatientsweremale(n =234,68.4%),whereas58.1%ofthepatientswere
maintainedontwice•weeklyhemodialysis.Temostcommonlyreportedcomorbiditieswerehypertensionanddiabetesmellitus.
Tefrequencyofdialysis(P < 0.01)andcomorbidities(P =0.009)hadasignifcantassociationwithanemiainMHDpatients.Te
majority of the patients had hyperparathyroidism (52%) with anemia. Upon performing binary logistic regression, multivariate
analysisdisplayedasimilaroddsvalueforhavinganemiainpatientswitheveryadditionalmonthinthedurationofhemodialysis
(OR1.01, P =0.001),theoddsofanemicpatientshavingapositiveantihepatitis•Cantibody(OR2.22, P =0.013),andtheoddsof
havinganemiainpatientsintheagecategorybelow45years(OR1.93, P =0.013).Inconclusion,thestudyresultsdepictthatevery
additional month in the duration of hemodialysis, age (<45 years), and positive anti•HCV antibody status, these variables were
more likely to have anemia in our study MHD patients. While in our fnal multivariate model, no statistically signifcant as•
sociation was observed between hyperparathyroidism and anemia.
Hindawi
International Journal of Clinical Practice
Volume 2023, Article ID 7418857, 12 pages
https://doi.org/10.1155/2023/7418857