Accepted Manuscript © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. One in every three COVID-19 reinfections result in hospitalization in the US Rafael H. Bastos, MD 1 ;Pedro K. Blos, MD 1 ; Valeria D. Rodrigues, MD; 1 Bruna da S. Miranda, MD, 1 Alessandro C. Pasqualotto, MD PhD 1 * 1 Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Brazil *Corresponding author. Alessandro C. Pasqualotto, M.D., Ph.D Molecular Biology Laboratory, Hospital Dom Vicente Scherer, Santa Casa de Misericordia de Porto Alegre. Av Independencia, 155, Centro, Porto Alegre, 90305- 075, Brazil. Email pasqualotto@ufcspa.edu.br Phone + 55 51 999951614.