Title page Pattern Breaking: A Complex Systems Approach to Psychedelic Medicine Inês Hipólito* Berlin School of Mind and Brain, Humboldt-Universität zu Berlin Faculty of Social and Behavioural Sciences, University of Amsterdam Wellcome Centre for Human Neuroimaging, University College London Jonas Mago Wellcome Centre for Human Neuroimaging, University College London Integrative Program in Neuroscience, McGill University Fernando E. Rosas Centre for Psychedelic Research, Department of Brain Sciences, Imperial College Lon- don Centre for Complexity Science, Imperial College London Data Science Institute, Imperial College London Department of Informatics, University of Sussex Centre for Eudaimonia and Human Flourishing, University of Oxford Robin Carhart-Harris Centre for Psychedelic Research, Department of Brain Sciences, Imperial College Lon- don Psychedelics Division, University of California San Francisco *Corresponding author ines.hipolito@hu-berlin.de Berlin School of Mind and Brain Luisenstraße 56 (Haus 1) Phone number (030) 2093-89755 Fax (030) 2093-89751 Mailing address Unter den Linden 6, 10099 Berlin 1