International Journal of Research in Medical Sciences | December 2017 | Vol 5 | Issue 12 Page 5406 International Journal of Research in Medical Sciences Das B et al. Int J Res Med Sci. 2017 Dec;5(12):5406-5409 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Pattern of lipid profile in type 2 diabetes mellitus-a study from north Bihar Bhagwan Das 1 , Durgesh Kumar 1 , Munish Kumar 2 * INTRODUCTION Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Type 2 Diabetes Mellitus (DM) is a heterogeneous group of disorders characterized by variable degree of insulin resistance, impaired insulin secretion, and increased glucose production. 1 The global burden of DM is enormous with an estimated 366 million people living with DM worldwide (2011). 2 India accounted for nearly one sixth of global diabetes burden in 2011 with about 62 million of people affected by diabetes which is projected to rise to 101 million by 2030. 2,3 Type2 DM is the most prevalent form of DM seen in India and constitutes more than 95% of diabetes population. Prevalence of diabetes is on an increase in India. According to National Urban Diabetes Survey (NUDS), the age standardized prevalence of diabetes and IGT were 12.1% and 14% respectively with no gender difference and that prevalence of diabetes is uniformly high in all urban cities of India (Chennai 13.5%, Bangalore 12.4%, Hyderabad 16.6%, Calcutta 11.7%, Mumbai 9.3%, and New Delhi 11.6%) but higher in southern cities. 4 It has been observed that Type2 DM in India occurs a decade earlier than in the developed world as shown by NUDS, Daryaganj survey, and CURE study, although the prevalence peaks at an older age. 4,5,6 The metabolic abnormalities that commonly accompany diabetes are disturbances in the production and clearance of plasma lipoproteins. In India, prevalence of dyslipidemia is 85.5% in male Type2 DM and 97.8% in female Type2 1 Department of Medicine, Sri Krishna Medical College, Muzaffarpur, Bihar, India 2 Department of Neurology, Sri Krishna Medical College, Muzaffarpur, Bihar, India Received: 14 October 2017 Accepted: 09 November 2017 *Correspondence: Dr. Munish Kumar, E-mail: munishpmch@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Type 2 Diabetes Mellitus (DM) is a heterogeneous group of disorders characterized by variable degree of insulin resistance, impaired insulin secretion, and increased glucose production. Methods: To study of pattern of lipid profile in type 2 diabetes mellitus, 100 cases of type 2 Diabetes Mellitus attending the tertiary care centre were selected. The result was compared with 25 healthy, non-obese, non- diabetic and non-hypertensive subjects. Results: Triglyceride (TG) and very low-density lipoprotein (VLDL) were significantly higher whereas high density lipoprotein (HDL) levels lower in diabetics than healthy controls. Total cholesterol (TC) and low-density lipoprotein (LDL) were other fractions which were slightly above optimal levels in diabetics. Conclusions: From our study, it was concluded that diabetes mellitus has a real impact on lipid metabolism. Keywords: Diabetes, Lipid Profile, North Bihar DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20175464