Accepted Manuscript Design and Evaluation of Novel 8-Oxo-pyridopyrimidine Jak1/2 Inhibitors Sharada Labadie, Kathy Barrett, Wade S. Blair, Christine Chang, Gauri Deshmukh, Charles Eigenbrot, Paul Gibbons, Adam Johnson, Jane R. Kenny, Pawan Bir Kohli, Marya Liimatta, Patrick J. Lupardus, Steven Shia, Micah Steffek, Savita Ubhayakar, Anne van Abbema, Mark Zak PII: S0960-894X(13)01022-6 DOI: http://dx.doi.org/10.1016/j.bmcl.2013.08.082 Reference: BMCL 20820 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 13 June 2013 Revised Date: 14 August 2013 Accepted Date: 19 August 2013 Please cite this article as: Labadie, S., Barrett, K., Blair, W.S., Chang, C., Deshmukh, G., Eigenbrot, C., Gibbons, P., Johnson, A., Kenny, J.R., Kohli, P.B., Liimatta, M., Lupardus, P.J., Shia, S., Steffek, M., Ubhayakar, S., Abbema, A.v., Zak, M., Design and Evaluation of Novel 8-Oxo-pyridopyrimidine Jak1/2 Inhibitors, Bioorganic & Medicinal Chemistry Letters (2013), doi: http://dx.doi.org/10.1016/j.bmcl.2013.08.082 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.