An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement Guilian Tian 1 , May Hui 1 , Desiree Macchia 1 , Pieter Derdeyn 2 , Alexandra Rogers 3 , Elizabeth Hubbard 1 , Chengfeng Liu 1 , Katrina Bartas 2 , Sean Carroll 1 , Kevin T. Beier 1, 3-7, # 1 Department of Physiology and Biophysics 2 Program in Mathematical, Computational, and Systems Biology 3 Department of Pharmaceutical Sciences 4 Department of Biomedical Engineering 5 Department of Neurobiology and Behavior 6 Center for the Neurobiology of Learning and Memory 7 UCI Mind, University of California, Irvine, Irvine, CA, 92617, United States # corresponding author Contact information: Kevin Beier 825 Health Sciences Road Medical Sciences D337 Irvine, CA 92697 Phone: 949-824-1083 Email: kbeier@uci.edu (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint this version posted November 7, 2021. ; https://doi.org/10.1101/2021.11.05.467532 doi: bioRxiv preprint