International Journal of Advances in Medicine | May-June 2018 | Vol 5 | Issue 3 Page 663 International Journal of Advances in Medicine Acharya A et al. Int J Adv Med. 2018 Jun;5(3):663-667 http://www.ijmedicine.com pISSN 2349-3925 | eISSN 2349-3933 Original Research Article A prospective study of pattern of hepatic dysfunction in dengue fever patient in coastal Andhra Pradesh, India Anand Acharya 1 , P. V. V. Satyanarayana 2 *, Vijjapu Subrahmanyam 3 INTRODUCTION Dengue is a mosquito born viral infection and is most common cause of arboviral disease in tropical and subtropical region. Four types of dengue virus exists DEN1, DEN2, DEN3 and DEN4, immunity to this is type specific so that it is possible for person to have four separate episodes of dengue fever. 1,2 At present DEN1, DEN2 and DEN3 is wide spread in India. Dengue has been classified in to • Dengue fever (DF) which is characterised by fever with least two of these features, muscle or joint pain, ABSTRACT Background: DENV (dengue viral infection) is a non-hepatotropic RNA virus, but hepatic involvement is common. High level of viremia is associated with involvement liver and other organs. Present study is a prospective study which is aimed to know about the, pattern of hepatic involvement in dengue patients admitted in General Medicine Dept Konaseema Institute of Medical Science. Methods: This is a prospective hospital-based study conducted in the Department of General Medicine Konaseema Institute of Medical Science Amalapuram Andhra Pradesh, from December 2015 to December 2017. During two year of study period 126 clinically and serologically positive patients of Dengue fever, Dengue haemorrhagic fever and Dengue shock syndrome, classified as per the, definition of national vector borne disease control programme Govt. of India. Results: Mean value of total bilirubin was 0.8 mg/dl in DF patients, 0.96mg/dl in DHF patients and 1.08mg/dl in DSS patients. Mean value of AST was 77.44(IU/L) in DF group, 112.32 IU/L in DHF group and 486.28 in DSS group. In DF group mean ALT in DHF group was 94.36 (IU/L) and it was 386.42 IU/L in DSS group. Mean value of serum albumin was 3.97 gm/dl in DF group, 3.65 gm/dl in DHF group and 3.49 gm/dl in DSS group. Serum globulin mean value was 2.98mg/dl in DF group, 2.86 gm/dl in DHF group and 2.69 gm/dl in DSS group. Serum alkaline phosphate level was also increased in all the groups, mean value of ALP was 118.46 IU/L in DF group, 164.32 IU/L in DF group, 164.32 IU/L in DHF patients and 342.42 IU/L in DSS group. Conclusions: The pattern of hepatic involvement of liver in dengue fever varies as per the severity of disease. In milder case of dengue fever liver function test was normal but there was hepatomegaly was present commonly but in severe form of disease pattern of hepatic involvement varies from tender hepatomegaly to significant increase in liver enzyme. Keywords: Coastal Andhra Pradesh, Dengue fever, Hepatic dysfunction 1 Department of Pharmacology, 2 Department of General Medicine, 3 Department of Medical Record, Konaseema Institute of Medical Science, Amalapuram, Andhra Pradesh, India Received: 05 March 2018 Accepted: 03 April 2018 *Correspondence: Dr. P. V. V. Satyanarayana, E-mail: anand_kims@yahoo.co.in Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-3933.ijam20182120