ELS Publishing Biofunct. Mat. Biofunct. Mat. 2023 (1):0003 1 https://doi.org/10.55092/bm20230003 Review Polymicellar-based drug delivery systems for use in nanodentistry, oral and cranio-maxillo-facial oncology Ziyad S. Haidar 1,2,3,4,5, * 1 BioMAT’X (HAiDAR I+D+i LAB), Santiago, Chile 2 Clínica/Hospital Universidad de los Andes, Santiago, Chile 3 Facultad de Odontología, Universidad de los Andes, Santiago, Chile 4 Programa de Doctorado en BioMedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile 5 Centro de Investigación e Innovación Biomédica (CiiB), Universidad de los Andes, Santiago, Chile * Corresponding author; E-mail: zhaidar@uandes.cl. Received 16 December 2022; Accepted 27 February 2023; Published 29 March 2023 Abstract: Polymer-based therapeutics is a precipitously-growing Research, Development and Innovation (R&D&I) translational field of bioengineering for biomedicine. The last decade has witnessed an exponential rise in interest from Dentistry, in general and Oral Oncology (extending to cranio-maxillo-facial), in particular. Basically, the area comprises the design, development, characterization, evaluation and fine-tuning (refinement) of polymer-drug and polymer-protein conjugates, macromolecular drug delivery systems, and polymeric micelles that incorporate covalently-bound drugs, bioactive agents and polyplexes for controlled pharmaceutic and DNA delivery. Accordingly, tackling drug delivery-related issues, including mode-of-administration, encapsulation efficiency, loading capacity, release pharmaco-kinetics, bio-safety and -efficacy became key in nanomedicine and nanoDentistry of today and tomorrow. Herein, nano-sized drug delivery vehicles and carriers can represent a cornerstone in the ongoing efforts for controlled drug development, formulation, optimization and translation from bench-top to chair-side; to the clinic and our patients. Indeed, the self-assembly of amphiphilic polymers, or aggregation colloids (in solution), commonly referred to as polymeric micelles, continue to represent an invaluably desirable and pursued small-scale, easy-to-formulate, -characterize and -sterilize tool in pharmaceutical innovation, mainly, in overcoming critical issues in drug delivery, including Copyright©2023 by the authors. Published by ELS Publishing. This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.