Anti diabetic (AD) studies of bis-glycine hydro bromide (45 nm) nano crystals K. Senthilkannan a,b,⇑ , Malarkodi Velraj c , Arockia Jenecius Alphonse d , Prithiviraj Nagarajan e a PG & Research Department of Physics, Edayathangudy G.S. Pillay Arts & Science College, Nagapattinam 611002, Tamilnadu, India b Dept. of R&D, Edayathangudy G.S. Pillay Arts and Science College, Nagapattinam 611002, Tamilnadu, India c Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science and Technology, Pallavaram, Chennai 600117, India d Department of Botany, St. Marys College (Autonomous), Thoothukudi 628001, Tamilnadu, India e Multi Disciplinary Centre for Biomedical Research, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission Research Foundation (Deemed to be University), Kirumampakkam, Puducherry 607403, India article info Article history: Received 4 April 2020 Accepted 13 April 2020 Available online xxxx Keywords: BGHB Ball milling XRD Nano Antidiabetic abstract In material applications nano materials and nano crystals are widely used and many utilization in all fields of science and technology. In this study we converted macro crystal into nano crystal by ball milling method, crystals are analysed by XRD method for parameters and the crystal is converted into nano crys- tals of 45 nm which are used for filter applications and anti diabetic study of the nano crystal inhibition values are increased with proper increase in the value of concentration, IC 50 values are 29.8 for Nano crys- tal of BGHB. Ó 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Nanotechnology: Ideas, Innovation and Industries. 1. Introduction Nano crystal is obtained from macro crystals by milling methodology. The crystal [1–5] is a solid whose molecules are arranged in repeating pattern and have geometrical shape in nano crystal the range is nearly 100 nm level. The nano crystals have numerous applications in electronics, biology and industries and here the AD activity is promptly discussed. 1.1. Synthesis of BGHB Bisglycine hydro bromide salt was orchestrated by dissolving glycine and hydro bromide corrosive in stoichiometric proportion (3:1) in twofold refined water. The arrangement was blended per- sistently utilizing an attractive stirrer. The acquired immersed arrangement was additionally refined and permitted to vanish at higher temperature which yields powder from of the incorporated material was filtered by rehashed recrystallization process. Modest seed gems with great straightforwardness were acquired because of unconstrained nucleation. Among them, an imperfection free seed precious stone was chosen and suspended in the mother arrangement, which was permitted to dissipate at room Large size single gems were acquired because of the assortment of monomers at the seed gem destinations from the arrangement, after the nucleation and development process were finished. Following a time of 24 days dismal and straightforward precious stones were gotten with measurements (17 Â 7 Â 6 mm 3 ) and milled to have nano crystals. 2. Characterisation 2.1. XRD Bis Glycine Hydro Bromide Nanocrystal having a = 5.39 Å, b = 8.17 Å c = 18.39 Å and a = c = 90°, b = 111.81°. It is monoclinic system and the crystal is milled for 30 h to get 45 nm of size of nano form of BGHB. SAMPLE CRYSTAL SIZE Initial powder 219 nm Milled after 30 h 45 nm https://doi.org/10.1016/j.matpr.2020.04.203 2214-7853/Ó 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Nanotechnology: Ideas, Innovation and Industries. ⇑ Corresponding author at: Edayathangudy G.S Pillay Arts and Science College, Nagapattinam 611002, India. E-mail address: mscgoldmedalist@yahoo.in (K. Senthilkannan). Materials Today: Proceedings xxx (xxxx) xxx Contents lists available at ScienceDirect Materials Today: Proceedings journal homepage: www.elsevier.com/locate/matpr Please cite this article as: K. Senthilkannan, M. Velraj, A. J. Alphonse et al., Anti diabetic (AD) studies of bis-glycine hydro bromide (45 nm) nano crystals, Materials Today: Proceedings, https://doi.org/10.1016/j.matpr.2020.04.203