Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction Mrinal K. Sarkar 1 , Ranjitha Uppala 1,2 , Chang Zeng 1 , Allison C. Billi 1 , Lam C. Tsoi 1 , Austin Kidder 1 , Xianying Xing 1 , Bethany E. Perez White 3 , Shuai Shao 1,4 , Olesya Plazyo 1 , Sirisha Sirobhushanam 5 , Enze Xing 1 , Yanyun Jiang 1,6 , Katherine A. Gallagher 7,8 , John J. Voorhees 1 , J. Michelle Kahlenberg 1,5,9 , Johann E. Gudjonsson *1,9 . 1. Department of Dermatology, University of Michigan, Ann Arbor, 48109, MI, USA 2. Graduate program in Immunology, University of Michigan, Ann Arbor, 48109, MI, USA 3. Department of Dermatology, Northwestern University, Chicago, 60611, IL, USA 4. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi, 710032, China. 5. Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 48109, USA 6. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 7. Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, 48109, MI, USA 8. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, MI, USA 9. Taubman Medical Research Institute, University of Michigan, Ann Arbor, 48109, MI, USA * Corresponding author: Johann E. Gudjonsson MD, PhD; 1301 Catherine St, 6427 Med Sci-I, Ann Arbor, MI-48109; e-mail: johanng@med.umich.edu; Tel: 734 615 4508, Fax: 734 647 0076