Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/cpt.1562 This article is protected by copyright. All rights reserved. SEVERE HYPONATREMIA IS OFTEN DRUG-INDUCED. 10-YEAR RESULTS OF A PROSPECTIVE PHARMACOVIGILANCE PROGRAM Elena Ramírez, Amelia Rodríguez, Javier Queiruga, Irene García, Lucía Díaz, Lucía Martínez, Raúl Muñoz, Mario Muñoz, Hoi Y Tong, José Carlos Martínez, Alberto M. Borobia, Antonio J. Carcas, Jesús Frías. Department of Clinical Pharmacology, La Paz University Hospital-Carlos III, IdiPAZ, School of Medicine, Autonomous University of Madrid, Madrid, Spain * Authors for correspondence: Elena Ramírez, Jesús Frías Department of Clinical Pharmacology, La Paz University Hospital -Carlos III, IdiPAZ, School of Medicine, Autonomous University of Madrid, Madrid, Spain Address: Paseo de la Castellana, 261, Madrid 28046 Tel/Fax: +34 91 7277559 E-mail: Elena Ramírez (elena.ramirez@inv.uam.es), Jesús Frías (jesus.frias@uam.es). Condensed Running Title “DRUG-INDUCED SEVERE HYPONATREMIA” Keywords: Adverse drug reaction; Hyponatremia; Pharmacovigilance; Automatic laboratory signals; Prospective pharmacovigilance program.