Accepted Manuscript An 18 bps in-frame deletion mutation in RUNX2 gene is a population polymorphism rather than a pathogenic variant Jamil Amjad Hashmi, Ahmad Almatrafi, Muhammad Latif, Abdul Nasir, Sulman Basit PII: S1769-7212(18)30349-5 DOI: 10.1016/j.ejmg.2018.06.013 Reference: EJMG 3491 To appear in: European Journal of Medical Genetics Received Date: 15 May 2018 Revised Date: 12 June 2018 Accepted Date: 26 June 2018 Please cite this article as: J.A. Hashmi, A. Almatrafi, M. Latif, A. Nasir, S. Basit, An 18 bps in-frame deletion mutation in RUNX2 gene is a population polymorphism rather than a pathogenic variant, European Journal of Medical Genetics (2018), doi: 10.1016/j.ejmg.2018.06.013. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.