Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cbdd.12985 This article is protected by copyright. All rights reserved. MR. HADI MOHAMMADI (Orcid ID : 0000-0003-2567-4944) Received Date : 24-Sep-2016 Revised Date : 01-Jan-2017 Accepted Date : 11-Mar-2017 Article type : Research Article A Comparison Inhibitory Effects of Cisplatin and MNPs-PEG- Cisplatin on the Adhesion Capacity of Bone Metastatic Breast Cancer Mohammad Javad Mokhtari 1 , Fatemeh Koohpeima 2 *, Hadi Mohammadi 3 * 1 Young Researchers and Elite Club, Zarghan Branch, Islamic Azad University, Zarghan, Iran. 2 Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Science, Shiraz, Iran. 3 Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran. *Corresponding Authors: Fatemeh Koohpeima Assistant professor, Department of Operative Dentistry, , School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Tel: +98-711-6263193 Email: koohpeima.f@gmail.com Hadi Mohammadi Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran Tel: +98 831 7265130 E. mail: hadimohammadi13@gmail.com Abstract To date, high mortality in women due to malignancy breast cancer related to the metastasis to the bone is a significant challenge. Since, magnetic nanoparticles (MNPs) conjugated with the biocompatible polymers was employed for the delivery of some hydrophobic anti-cancer agents, so the main aim of the current research was to assess whether cisplatin-loaded MNPs enhanced the anti-cancer effect of free cisplatin in breast cancer cells.MNPs decorated with PEG were synthesized by an improved co-