Polymorphic Variation of CYP1A1 and CYP1B1 Genes in a Haryana Population Shiv Kumar Giri • Anita Yadav • Anil Kumar • Kapil Dev • Sachin Gulati • Ranjan Gupta • Neeraj Aggarwal • Sanjeev Kumar Gautam Received: 13 July 2012 / Accepted: 26 March 2013 Ó Springer Science+Business Media New York 2013 Abstract Cytochrome P450 (CYP) 1A1 and CYP1B1 are important phase I xenobiotic metabolizing enzymes involved in the metabolism of numbers of toxins, endogenous hormones, and pharmaceutical drugs. Polymorphisms in these phase I genes can alter enzyme activity and are known to be associated with cancer sus- ceptibility related to environmental toxins and hormone exposure. Their genotypes may also display ethnicity-dependent population frequencies. The present study was aimed to determine the frequencies of commonly known functional polymorphisms of CYP1A1 and CYP1B1 genes in a Haryana state population of North India. The allelic frequency of CYP1A1 polymorphism m1 (MspI) was 29.65% and m2 (Ile 462 Val) was 24.85%. The frequency of CYP1B1 polymorphism m1 (Val 432 Leu) was 45.85% and m2 (Asn 453 Ser) was 16.2%. We observed inter- and intra-ethnic variation in the frequency distribution of these polymorphisms. Analysis of poly- morphisms in these genes might help in predicting the risk of cancer. Our results emphasize the need for more such studies in high-risk populations. Keywords CYP1A1 Á CYP1B1 Á Polymorphism Á Haryana population Á Allele frequency Á Cancer S. K. Giri Á A. Yadav (&) Á A. Kumar Á K. Dev Á S. Gulati Á S. K. Gautam Department of Biotechnology, Kurukshetra University, Kurukshetra 136119, Haryana, India e-mail: ayadav@kuk.ac.in R. Gupta Department of Biochemistry, Kurukshetra University, Kurukshetra 136119, Haryana, India N. Aggarwal Department of Microbiology, Kurukshetra University, Kurukshetra 136119, Haryana, India 123 Biochem Genet DOI 10.1007/s10528-013-9612-y