ORIGINAL PAPER Serum Uric Acid and Impaired Glucose Tolerance: The Cardiometabolic Risk in Chinese (CRC) Study Qinqin Qiu • Ying Gong • Xuekui Liu • Lianjun Dou • Yu Wang • Ben Wang • Jun Liang Ó Springer Science+Business Media New York 2015 Abstract Serum uric acid (SUA) elevation has been pre- viously related to impaired fasting glucose and type 2 dia- betes. The present study was comprehensive to examine the associations between SUA and impaired glucose tolerance (IGT) in Chinese adults. For this purpose, data were collected from a community-based health examination survey con- ducted in Central China; 2-h glucose (OGTT) and SUA were measured in 1956 men and women. In multivariate models, SUA levels were significantly associated with an increasing trend of 2-h glucose (OGTT) (P for trend \ 0.0001). The odds ratios (OR; 95 % CI) of IGT across increasing quartiles of SUA were 1.0, 1.354 (0.948–2.087), 1.337 (0.959–2.251), and 2.192 (1.407–3.416), after adjusting for age, sex, body mass index, waist circumference, fasting insulin, blood pressure, serum lipids, serum creatinine, and estimated glomerular filtration rate. (P for trend = 0.001). In addition, we found an additive pattern between SUA and triglyceride (TG; P = 0.038) or between SUA and low-density lipoprotein cholesterol (LDL-C; P = 0.041) in relation to IGT. SUA was related to IGT in the Chinese adults, independent of other conventional metabolic risk factors. TG and LDL-C might modify the associations. Keywords Serum uric acid Á Impaired glucose tolerance Á Triglyceride Á Low-density lipoprotein cholesterol Abbreviations SUA Serum uric acid IGT Impaired glucose tolerance 2-h glucose (OGTT) 2-hour glucose (oral glucose tolerance test) BMI Body mass index WC Waist circumference SBP Systolic blood pressure DBP Diastolic blood pressure HOMA-IR Homeostasis model assessment of insulin resistance HbA1c Glycated hemoglobin FBG Fasting blood glucose FPG Fasting plasma glucose FINS Fasting insulin TC Total cholesterol TG Triglycerides HDL-C High-density lipoprotein cholesterol LDL-C Low-density lipoprotein cholesterol OR Odds ratio CI Confidence interval eGFR Estimated glomerular filtration rate Introduction Serum uric acid (SUA), a degradation metabolite of puri- nes, has been recently associated with metabolic syndrome [1, 2], non-alcoholic fatty liver disease [3, 4], and Qinqin Qiu, Ying Gong and Jun Liang have contributed equally to this work. Q. Qiu Á Y. Wang Xuzhou Medical College, Xuzhou 221009, Jiangsu, China Y. Gong Á X. Liu Á L. Dou Á Y. Wang Á B. Wang Á J. Liang (&) Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou 221009, Jiangsu, China e-mail: mwlj521@163.com Y. Gong Á X. Liu Á L. Dou Á Y. Wang Á B. Wang Á J. Liang Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou 221009, Jiangsu, China 123 Cell Biochem Biophys DOI 10.1007/s12013-015-0597-5