International Journal of Virology and Molecular Biology 2022, 11(1): 3-8 DOI: 10.5923/j.ijvmb.20221101.02 Immunorehabilitation of Patients with Echinococcosis, Complicated by the Satellites of Echinococcal Cysts-Bacteria Vakhidova A. M. 1,* , Khudoyarova G. N. 1 , Khudzhanova M. A. 2 , Mamedov A. I. 1 1 Department of Microbiology, Virology and Immunology, Samarkand State Medical Institute, Samarkand, Uzbekistan 2 Assistant of the Department of Normal Physiology, Samarkand State Medical Institute, Samarkand, Uzbekistan Abstract The purpose of the work. To determine the frequency of complications in immune disorders in patients with echinococcosis, and to study immunocorrective and biostimulating therapeutic measures. Materials and methods of research. Parasitological, histological, biochemical, immunological, serological, ultrasound and X-ray examinations were used. Results. In the early stages of the disease, when clinical manifestations are absent or insignificant, the diagnosis of echinococcosis is particularly difficult. Therefore, uncomplicated echinococcosis is often detected accidentally during preventive examinations. We observed 72 patients with echinococcosis of the lung at the age of 2 to 16 years. Depending on the period of the disease, they were divided into 3 groups: in the initial stage - 3 patients, in the midst of the disease - 36, in the stage of complications - 33 patients. As is known, the most informative method of diagnosing echinococcosis of the lungs is radiography, while a typical picture is observed depending on the stage of the disease and the size of the cyst. Echinococcosis of the lungs is often difficult to differentiate from an abscess and a lung tumor, as well as from pyopneumothorax, pyothorax. Therefore, chest X-ray examination is an important and valuable method for diagnosing lung echinococcosis, but it is not without drawbacks: its use does not allow to detect lung echinococcosis with a 100% guarantee. In 5.8% of the observations, diagnostic errors were made. But the most reliable methods of diagnosing echinococcosis, or rather the presence of echinococcus in the body, are immunological. In the experiment, the sensitivity and specificity of RLA, RNGA, ELISA, TIM, and PCR were tested on a sufficient number of animals of different species. However, the specificity of these reactions did not exceed 82%, with the exception of RSKP (accuracy of readings up to 94.5%), which corresponds to the materials of our publications. Conclusions. We noted that the detection and complete recovery from the main disease, complete recovery of working capacity, the absence of any complaints, with X-ray examination-the absence or insignificant area of pneumofibrosis in the lung; in some periods, negative serological reactions (RLA, RNGA, RDDH), as well as long- tomography, ultrasound scanning, radiography) and serological methods is used. Keywords Serological reactions, Echinococcosis, Radiography, Lung, Immune disorders 1. Introduction For the diagnosis of echinococcosis, a complex of clinical, instrumental (computed term results were obtained after 1.5-2 years, which indicates that ventilation is being restored in the operated lung. However, it is not easy to identify the pathology. Diagnostic errors occur in 4-8% of cases when abscesses and tumors of the liver, lungs, pleural empyema, etc. are detected during surgery. Since the 70s of the XX century, much attention has been paid to specific methods of immune diagnosis of echinococcosis. However, the analysis of the literature data showed an ambiguous assessment of * Corresponding author: adola.ru@mail.ru (Vakhidova A. M.) Received: Feb. 16, 2022; Accepted: Mar. 6, 2022; Published: Mar. 9, 2022 Published online at http://journal.sapub.org/ijvmb their diagnostic capabilities. Thus, false-positive and negative results in the reaction of indirect hemagglutination (RNGA) were observed in 17-45% of cases. Thus, the development of new approaches to the immunodiagnostics of echinococcosis in children and adults remains an urgent problem. The influence of morphological modifications of the exciter on the clinical course and outcome of the disease has been poorly studied. The purpose of the work: The goal of surgical intervention is not only to remove the echinococcal cyst in the most gentle way, but also to prevent complications of the disease — residual cavities in the operated organs and relapses of echinococcosis. Despite the large number of options for surgical approaches to the treatment of echinococcosis, the complication rate remains quite high (21%), and the mortality rate among children ranges from 7 to 16%. Given the deep immune disorders in patients with