REGULAR ARTICLE Association between inflammation, lipid and hemostatic factors in patients with stable angina Jose´ D. Sagastagoitia a , Yolanda Sa ´ez b , Marta Vacas b, * , Idoia Narva ´ez b , Jesu´sP.Sa ´ez de Lafuente c , Enrique Molinero a , Ana Magro b , Manuel Lafita b ,Mo´nicaSantos b , Antonio Escobar d , Jose´A. Iriarte b a Servicio de Cardiologı ´a, Hospital de Basurto, Departamento Medicina, Universidad del Paı ´s Vasco UPV/EHU, Bilbao, Spain b FIDEC-Fundacio ´n para la Investigacio ´n y Docencia de las Enfermedades Cardiovasculares, Bilbao, C/Gurtubay s/n 48013, Bilbao, Spain c Escuela Universitaria de Enfermerı ´a, Universidad del Paı ´s Vasco UPV/EHU, Bilbao, Spain d Unidad de Investigacio ´n, Hospital de Basurto, Bilbao, Spain Received 1 March 2006; received in revised form 27 June 2006; accepted 28 June 2006 Available online 17 August 2006 Abstract Introduction: Dyslipidemia and thrombotic processes are both clearly involved in atherogenesis and its secondary complications. Moreover, inflammation has also been shown to play an important role in the pathophysiology of atherosclerosis. Our objective was to determine the association between inflammation, lipids and thrombosis in a group of patients with stable angina. Patients and methods: 295 patients (217 males and 78 females) with a mean age of 65.69 F 11.24 years. Levels of C-reactive protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), apolipoproteins A1 and B100, fibrinogen and D-dimer were determined for each. Results: Arithmetic and geometric means of C-reactive protein in the sample were 10.7 and 1.4mg/l, respectively. Distributing the sample by quartiles of C-reactive protein, we found a positive correlation between C-reactive protein, fibrinogen and D-dimer levels ( p b 0.000), and an inverse correlation for HDL cholesterol and apolipoprotein A1 ( p b 0.000). In multivariate analysis, fibrinogen ( p b 0.000) and D- dimer ( p b 0.01) levels were independently associated with high levels of C-reactive protein. Of the lipid factors, only apolipoprotein A1 ( p b 0.000) was independently 0049-3848/$ - see front matter D 2006 Elsevier Ltd. All rights reserved. doi:10.1016/j.thromres.2006.06.013 Abbreviations: Lp(a), lipoprotein(a); BMI, body mass index; CRP, C-reactive protein; Apo A1, apolipoprotein A1; Apo B100, apolipoprotein B100; HDLc, HDLC-cholesterol; LDLc, LDL-cholesterol. * Corresponding author. Tel.: +34 946017450; fax: +34 944421488. E-mail address: bdbvarim@lg.ehu.es (M. Vacas). KEYWORDS Inflammation; Lipids; Hemostatic factors; Thrombosis; Stable angina Thrombosis Research (2007) 120, 53—59 intl.elsevierhealth.com/journals/thre