How to Cite: Gupta, S., Sharma, M., Kumar, M., Dabla, U., Prakash, S., & Sangra, V. (2022). Biofluids in orofacial pain: Review. International Journal of Health Sciences, 6(S3), 3409–3418. https://doi.org/10.53730/ijhs.v6nS3.6475 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 Dec 2021, Manuscript revised: 09 March 2022, Accepted for publication: 18 April 2022 3409 Biofluids in orofacial pain: Review Dr. Shweta Gupta Pg Student, Dept. of Oral Pathology, Surendera Dental College & Research Institute Sriganganagar Rajasthan Email: shwetagupta2012@gmail.com Dr. Manish Sharma Prof & Head, Dept. Of Oral Pathology, Surendera Dental College & Research Institute Sriganganagar, Rajasthan Email: drmanishsharma2007@gmail.com Dr. Manish Kumar Reader, Dept. Of Oral Pathology, Surendera Dental College & Research Institute Sriganganagar, Rajasthan Email: drmanish84@gmail.com Dr. Uma Dabla BDS,MDS, Dept of Oral Pathology Email: uma.dabla92@gmail.com Dr. Satya Prakash Senior lecturer, Oral and Maxillofacial Surgeon, J. C. D Dental College Sirsa, Haryana Email: pSatya345@gmail.com Dr. Vidhi Sangra BDS, MDS, Oral and Maxillofacial Surgery Email: Vidhi.sangra@gmail.com Abstract---Orofacial pain is a dental specialty that focuses on diagnosing and treating long-term, complicated facial discomfort caused by oromotor disorders. This pain is similar to pain elsewhere in the body and is generally caused by tissue damages. The pathogenesis of orofacialpain might be caused by orofacial structures illness, musculoskeletal system disorders, peripheral or central nervous system disorders, systemic diseases, psychological problems, or the result of inadequate sleep. One method to diagnose is evaluating the molecular and microbial cues of biological fluids, which may indicate the occurrence or progression of the disease. This article provides an overview of these biofluids and biomarkers and their role in progression of orofacial diseases.