Supplementary Material Plan‐Do‐Study‐Act approach for IMPlementing split Regimen OVEr Single dose (IMPROVES study) Giuseppe Vanella 1 , Cesare Hassan 2 , Mario De Bellis 3 , Maxemiliano Giardini 4 , Enrico Grasso 5 , Francesco Laterza 6 , Ottaviano Tarantino 7 , Emilio Di Giulio 1 1. Sant’Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy 2. Nuovo Regina Margherita Hospital, Rome, Italy 3. Istituto Nazionale Tumori – IRCCS – Fondazione G. Pascale, Naples, Italy 4. Urbino Hospital, Urbino, Italy 5. Tor Vergata University, Rome, Italy. 6. Gabriele d’Annunzio University and Foundation, Chieti, Italy. 7. San Giuseppe Hospital, Empoli, Italy SUPPLEMENTAL INFORMATION Methods Statement 1 The following information were registered through an anonymous electronical case report form (CRF): 1) Patient characteristics: age, sex, education, comorbidities, inpatient versus (vs) outpatient status, distance between home and the endoscopic centre; first vs successive colonoscopy 2) Bowel cleansing: substance (4L- PEG + simethicone, 2L-PEG + ascorbate, 2L-PEG + citrate + bisacodyl, sodium phosphate, sodium picosulfate + magnesium citrate), regimen (DB, SpD, SaD), fraction of product consumed, timing of regimen consumption, patient satisfaction and willingness to repeat the regimen; 3) Preparation choice: how the preparation was prescribed (central independent reservation system, module from the endoscopic unit, visit with endoscopy personnel, other oral information, other written information), if an alternative was provided between a split-dose or a day-before regimen; 4) Colonoscopy: indication, prescriber, planned time; effective time, sedation, cecal intubation, right colon preparation, left colon preparation, endoscopist satisfaction about the bowel cleansing; consequences of an unadequate preparation (repetition of the exam, shortening of FU interval, neither); Statement 2 The following continuous variables were categorized. Scheduled colonoscopy time = before 9:30 am; between 9:30 and 11:30 am; between 11:30 am and 2 pm and after 2 pm (afternoon colonoscopies).