_____________________________________________________________________________________________________ ≡ Intern; ‡ Assistant Professor *Corresponding author: E-mail: senguptakritarth16@gmail.com; Journal of Pharmaceutical Research International 33(60A): 948-955, 2021; Article no.JPRI.71059 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Diabetes Mellitus: Worst Comorbidity to have in COVID-19 Pandemic Kritarth Sengupta a*≡ and Bharat S. Sudame b‡ a Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha-442001, Maharashtra, India. b Department of Electrical Engineering, Yeshwantrao Chavan College of Engineering, Nagpur, India. Authors’ contributions This work was carried out in collaboration between both authors. Both authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i60A34571 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/71059 Received 14 November 2021 Accepted 20 December 2021 Published 21 December 2021 ABSTRACT Background: Diabetic patients have shown the worst clinical manifestation of the COVID-19. They are at higher risk of being infected and producing severe clinical outcomes, challenging to manage. Also, the share of the diabetic patient among case fatalities is large. Summary: COVID-19 is a disease pandemic that has spread worldwide. All sections and age groups of people worldwide have been affected by the pandemic. Diabetes mellitus is the worst disease to have in OVID-19, as studies have shown some adverse clinical outcome that needs sophisticated medical attention. In lack of resources and overwhelmed infrastructure, the availability of these is tricky. Conclusion: More study is needed about the bidirectional relationship between COVID-19 and diabetes mellitus so that a clearer picture can be emerged out of the fogged situation. Diabetes is already grappling the world, which is suggested by increasing the number of diabetic patient’s number worldwide. Especially in COVID-19, it has become a challenge to contain the disease along with all these comorbidities. The immunosuppressive state brought about by various underlying medical conditions like diabetes mellitus is suitable ground for novel coronavirus to propagate itself. Review Article