Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/1440-1681.13162 This article is protected by copyright. All rights reserved. DR. RABAB SAYED (Orcid ID : 0000-0002-5337-3658) Article type : Original Article Hypoxia-inducible factor 1 alpha and nuclear related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson’s disease Esraa A. Kandil a , Rabab H. Sayed a , Lamiaa A. Ahmed a , Mai A. Abd El Fattah a , Bahia M. El-Sayeh a a Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt Corresponding author: Rabab Hamed Sayed Postal address: Faculty of Pharmacy, Kasr El Aini St, 11562 Cairo, Egypt Fax number: +202-23628426 Mobile number: +201001414473 E-mail:rabab.sayed@pharma.cu.edu.eg Running title: Albendazole in Parkinson’s disease 1 1 List of Abbreviations ABZ, Albendazole; CoREST, Corepressor for repressor element 1 silencing transcription factor; DA, Dopamine; GDNF, Glial cell line-derived neurotrophic factor;HIF-1α, Hypoxia-inducible factor-1 alpha; NF- кB, Nuclear factor kappa beta; Nurr1, Nuclear receptor related 1;PD, Parkinson's disease; SN, Substantia nigra;TH, Tyrosine hydroxylase;TNF-α, Tumor necrosis factor alpha;VEGF, Vascular endothelial growth factor; VMAT, Vesicular monoamine transporter.