Solanki HK et al. American Journal of Cancer Biology 2015, 2:1-8 Antimutagenic Potential of Probiotic Lactobacillus Sporogenes Using Ames Assay Himanshu K. Solanki 1* , Dushyant A. Shah 2 , Jalaram H. Thakkar 3 1 Department of Pharmaceutics, SSR College of Pharmacy, India 2 APMC College of Pharmaceutical Education and Research, India 3 Department of Pharmacology, SSR College of Pharmacy, India Keywords : Anti-mutagenicity; Sodium azide; Salmonella typhimurium; Ames test; Lactobacillus sporogenes Academic Editor : XiaoningPeng, PhD, Department of Internal Medicine, Hunan Normal University, China Received: April 29, 2015; Accepted: May 29, 2015; Published: August 19, 2015 Competing Interests : The authors have declared that no competing interests exist. Copyright : 2015, Solanki HK et al . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. * Correspondence to : Himanshu K. Solanki, Department of Pharmaceutics, SSR College of Pharmacy, India Email : solanki_hims@yahoo.co.in Abstract Objective: Probiotic are beneficial microbial nutrition supplements which have useful effects on human health by conserving of bowel microbial balance. There are many studies that have been recommended the use of probiotic products as cancer risk reducer. The aim of present study was to investigate antimutagenic potential of Probiotic Lactobacillus sporogenes against TA98 and TA100 strain of Salmonella typhimurium. Material and Methods: Ames test was used in the present investigation to evaluate antimutagenic activity in TA98 and TA100 strains of Salmonella typhimurium using direct acting mutagens (Sodium azide) and different concentration of Probiotic L.Sporogenes (25, 50, 100 and 500 μg/0.1 ml/plate). Results: Probiotic Lactobacillus sporogenes showed significant anti-mutagenicity against mutagen sodium azide in TA98 and TA100 tester strains whereas it showed anti-mutagenicity result in inhibition of 93-97% and 62-88% of his + revertants induced by sodium azide in TA98 and TA100 strains respectively. Conclusion: The anti-mutagenicity of Probiotic Lactobacillus sporogenes the observed in the present study implies chemopreventive pharmacological importance of Probiotic Lactobacillus sporogenes and encourages its use as a biotherapeutic agent. American Journal of Cancer Biology http://ivyunion.org/index.php/ajcb/ Research Article