128 537 Board #2 May 28, 1:00 PM - 3:00 PM The Effect Of Chemotherapy Treatment For Colon Cancer On Physical Function And Physical Activity Negin Niksirat 1 , Howard Lim 2 , Teresa Liu-Ambrose 1 , Kristin Campbell 1 . 1 University of British Columbia, Vancouver, BC, Canada. 2 British Columbia Cancer Centre, Vancouver, BC, Canada. (Sponsor: Kerri Winters-Stone, FACSM) (No relationships reported) Deficits in physical function and mobility are observed among those with a recent cancer history, as well as, long-term cancer survivors. To date, the majority of research documenting these deficits has been undertaken in individuals with breast, lung, and prostate cancer. A decrease in physical activity participation has been shown among individuals being treated for colorectal cancer over the course of chemotherapy. However, to date, a change in physical function and mobility of colon cancer patients over the course of chemotherapy has not been assessed. Furthermore, the impact of physical activity levels on physical function and mobility has not been explored. PURPOSE: To examine if there is a change from baseline to 6 months (end of chemotherapy) in physical function, mobility and leisure-time physical activity levels in newly diagnoses colon cancer patients scheduled to receive 5-fluorouracil/Oxaliplatin as an adjuvant chemotherapy treatment. METHODS: For this prospective longitudinal pilot study, we recruited colon cancer patients prior to the first bout of chemotherapy (baseline). At baseline and 6-months, participants completed a functional mobility testing battery, including timed up and go (TUG), gait speed (GS), and 6-minute walk test (6MWT). Self-reported physical activity was assessed by the International Physical Activity Questionnaire (IPAQ) and scored as MET-hrs/week. RESULTS: Four participants (mean age = 53 ± 4 yr) have completed the two study visits. At baseline the scores of TUG, GS, 6MWT, and leisure-time physical activity were 4.42 ± 0.83 s, 1.76 ± 0.50 m/s, 628.40 ± 48.24 m, 28.30 ± 21.60 MET-hrs/week, respectively. No significant changes were observed at 6-months for TUG (0.38 ± 0.25 s, p=0.13), GS (0.11 ± 0.22 m/s, p=0.38), 6MWT (10.10 ± 35.75 m, p=0.88), or leisure-time physical activity (-18.93 ± 15.61, MET-hrs/week, p=0.18). CONCLUSION: There was no change in the functional mobility and physical activity levels noted from baseline to the end of chemotherapy in our current sample. Data collection is ongoing. 538 Board #3 May 28, 1:00 PM - 3:00 PM Is The ACSM’s Classification Of Exercise Intensities Valid For Breast Cancer Survivors? Friederike Scharhag-Rosenberger 1 , Rea Kühl 1 , Kai Schommer 2 , Oliver Klassen 1 , Cornelia M. Ulrich 1 , Joachim Wiskemann 1 , Karen Steindorf 1 . 1 National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany. 2 University Hospital Heidelberg, Heidelberg, Germany. (Sponsor: Jürgen Scharhag, FACSM) (No relationships reported) PURPOSE: The American College of Sports Medicine (ACSM) offers intensity classifications for endurance training prescription in healthy individuals which are defined as percentages of oxygen uptake reserve (%VO2R), heart rate reserve (%HRR), maximal oxygen uptake (%VO2max), and maximal heart rate (%HRmax). This classification is also used in cancer survivors, although chemotherapy (CTx) and radiotherapy (RT) might impact the relationship between the above mentioned parameters. Therefore, the vali dity of the ACSM’s classification of exercise intensities was investigated in breast cancer survivors. METHODS: 52 women with breast cancer (stage 0-III, age 52±9 yrs, BMI 25.4±3.5 kg/m2, no regular exercise training) performed a maximal stepwise incremental cycling test with gas exchange measurements between 2 weeks before and 12 weeks after end of therapy (surgery+CTx+RT: N=31, surgery+RT: N=20, surgery+CTx: N=1). Individual linear regression equations between %VO2R (reference) and %HRR, %VO2max, and %HRmax were calculated from the data at the end of each exercise stage. Testing for statistically significant differences was based on overlapping of the 95% confidence intervals of observed data with ACSM’s data. RESULTS: 30, 40, and 60 %VO2R corresponded to 58±12, 64±11, and 77±7 %HRmax, which was not significantly different from ACSM’s 57, 64, and 77 %HRmax. However, 30, 40, and 60% VO2R corresponded to 42±4, 50±3, and 67±2 %VO2max, which was significantly higher than ACSM’s 37, 46, and 64 %VO2max. Furthermore, 30, 40, and 60 %VO2R corresponded to 12±22, 25±19, and 51±13 %HRR, which was significantly lower than ACSM’s 30, 40, and 60 %HRR. CONCLUSIONS: The ACSM’s intensity classification for training prescription is valid for breast cancer survivors only if %HRmax is used. %VO2max results in mildly too low and %HRR results in markedly too high exercise intensities in breast cancer survivors according to the ACSM’s classification and, therefore, should not be used. Further research is required to evaluate adequate methods of intensity prescription in this population. 539 Board #4 May 28, 1:00 PM - 3:00 PM Effects Of Physical Activity With Antigravity Treadmill Training On Physiological Measures In Breast Cancer Patients. Ciaran Fairman 1 , Kristina Kendall 1 , Brandonn Harris 1 , Jim McMillan 1 , Jason Crandall 2 , Parker Hyde 1 . 1 Georgia Southern University, Statesboro, GA. 2 Western Kentucky University, Bowling Green, KY. (No relationships reported) Physical activity (PA) has been concluded to be a safe and effective mode of treatment effects breast cancer survivors both during and post treatment. However, some survivors experience lower bone mineral density and may be at a higher risk for osteoporosis and consequent falls and injuries. This has lead to research investigating low impact exercises with survivors, with researchers examining the use of a water-based exercise programs to unweight the participant and lower the impact even further. This study aimed to build on studies with lower impact exercise programs by using an antigravity (Alter-G®) treadmill to administer cardiovascular training. PURPOSE:The purpose of this study was to determine the effectiveness a physical activity program including an anti-gravity (Alter-G) treadmill aid in improving physiological and psychosocial measures in female breast cancer survivors. METHODS: Five female breast cancer survivors were recruited to participate in the study. A 14-week intervention using an AB-AB was employed. The program consisted of muscular strength and endurance, and cardiovascular endurance exercises. Consistent with current literature and guidelines, exercise interventions were individualized and tailored to suit individuals. RESULTS:Visual analysis of results found improvements in flexibility, cardiovascular endurance, and measures of body composition. Resting heart rate and blood pressure were maintained throughout the program. CONCLUSIONS:The results of this study suggest that participation in a 14-week supervised intervention with the inclusion of an Anti-gravity treadmill may provide practical and meaningful improvements in physiological and psychosocial variables in female breast cancer survivors. The results of this study illustrate that the use of an Alter-G treadmill as an alternative mode of cardiovascular exercise may illicit meaningful improvements in endurance and body composition. 540 Board #5 May 28, 1:00 PM - 3:00 PM Effect of Rest Interval on Muscle Performance in Breast Cancer Survivors Carlos A. Vieira 1 , Joao B. Ferreira-Junior 2 , Amilton Vieira 3 , Sandro J. Martins 3 , Maria F. Vogt 3 , Ruffo Freitas Junior 1 , Claudio L. Battaglini 4 , Martim Bottaro 3 . 1 Federal University of Goias, Goiania, Brazil. 2 Federal Institute of Triangulo Mineiro, Paracatu, Brazil. 3 University of Brasilia, Brasilia, Brazil. 4 University of North Carolina at Chapel Hill, Chapel Hill, NC. (No relationships reported) Copyright © 2014 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.