Thematic Special Issue: Modern Drug Discovery – Current Challenges & Future Perspectives 2022 | 127 STUDIES ON POLY HERBAL POWDER SHAMPOO FOR THE TREATMENT OF PEDICULOSIS CAPITIS AND PITYRIASIS CAPITIS INFESTATIONS Original Article JAMAL MOIDEEN MUTHU MOHAMED 1 , GAMAL OSMAN ELHASSAN 2 , JIYAUDDIN KHAN 3 , R. A. M. JAINAF NACHIYA 4* , SAMINATHAN KAYAROHANAM 5 , ASHOK KUMAR JANAKIRAMAN 6 1 College of Pharmacy, Shri Indra Ganesan Institute of Medical Science, Manikandam, Tiruchirapalli 620012, Tamil Nadu, India, 2 Department of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Sauadi Arabia, 3 Department of Pharmaceutics, School of Pharmacy, Management and Sciences University. Shah Alam, Selangor, Darul Ehsan, Malaysia, 4 Crescent School of Pharmacy, BS Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai 600048, India, 5 Faculty of Bio-economy and Health Sciences, Geomatika University College Kuala Lumpur 54200, Malaysia, 6 Faculty of Pharmaceutical Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia Email: jainafrazak786@gmail.com Received: 15 Apr 2021, Revised and Accepted: 30 May 2022 ABSTRACT Objective: The main objective of this study was to the formulation containing polyherbal medicinal plants, which gives safety, and efficacy; rectify skin disease, scalp disorders and reducing the harmful effect from herbal anti-lice and dandruff shampoos for the treatment of Pediculosis capitis and Pityriasis capitis and to prevent hair fall. Methods: The formulation of herbal shampoo with various herbal ingredients were dried, milled, sieved (120#) and mixed in geometrical order and evaluated their physicochemical characteristics. Furthermore, particle characters, organoleptic properties, foaming index, skin irritation study, and Anti-lice activity were performed. Results: The prepared poly herbal powdered shampoo (PHPS) exhibits that was freely soluble, particle 20-25 μm size range and free-flowing powder. Lest moisture content (2.5%), ash value, acid value and reduced surface tension of liquid are referred as an ideal candidate for foaming, anti-lice potential with no skin irritations. Conclusion: Based on the evaluation parameters, the prepared powdered shampoo helps to remove hair grease, no hair fall and strengthen hair follicles. Preparation of PHPS formulation at laboratory scale and the compounding of several ingredients of herbal source have produced it possible to ensure safety, efficacy and secure highly effective PHPS. Keywords: Pediculosis capitis, Pityrosis capitis, Polyherbal powder, Shampoo, Anti-lice activity © 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/) DOI: https://dx.doi.org/10.22159/ijap.2022.v14ti.37 Journal homepage: https://innovareacademics.in/journals/index.php/ijap INTRODUCTION Pediculosis capitis and Pityriasis capitis (head lice) is one of the most common ecto-parasitic infestations. It is widely affected, with youngsters aged 6 to 13 y being the most prevalent sufferers. The youngster may experience significant social anguish, discomfort, parenteral anxiety, and humiliation as a result of pediculosis capitis. Pityriasis capitis is a common scalp disorder, and it is a chronic dermatitis of this condition and tendency to relapse makes it difficult to manage for people suffering from this fungal infection in the form of flaky white to Yellowish scales. Yeast is a kind of organism that lives Malassezia furfur is the principal dandruff- producing bacteria, and its lipase activity distributes free fatty acids into the skin, causing irritation and tissue damage [1]. Malassezia restricta and Malassezia globosa are fungi that produce pityrosis capitis (dandruff infestation). Malassezia, formerly known as Pityrosporum, is a yeast that causes skin and scalp infections [2]. The Pediculosis capitis and Pityrosis capitis are commonly afflicted with adolescents and the overall prevalence was 16.5% and 17.1%, respectively. The natural composition of the herbs has no negative effects on the human body but instead enriches it with nutrients and other beneficial minerals [3]. Present study is to examine the pediculicidal infestation like lice and dandruff in the scalp and the main objective was poly herbal powder shampoo (PHPS) containing shikakai, henna, reetha, Indian gooseberry, hibiscus, Avaram senna, vetiver roots, neem, curry leaves bringraj and rose flowers with on safety, efficacy which will rectify the problem of sebaceous disorders, skin-scaling disorders and economically reduce manufacturing cost. The Shikakai (Acacia concinna linn) is a medicinal plant; the fact; that the pods of this plant are known to contain many saponins based on acacia acid, prior chemical examinations only resulted in the discovery of flavonoid and mono terpenoids for the Indian herbal sector [4]. The Henna (Lawsonia inermis) plants is useful to treat plant, animals and humans diseases from the ancient period and other herbal plants like Vetiver, curry leaves (Murraya koenigil), Bringraj (Eclipta 127oliates127) and Rose flowers (Rosa Gallica offinalis) which gives as strengthens hair follicles, coolant, conditioning and fragrance [5]. Reetha (Sapindustri 127oliates Linn, Sapindaceae), which is known as soapnut and it is used as antibacterial, antifungal and insect repellent, etc. Amla, often known as Indian Gooseberry (Emblica officinalis Gaertn, Euphorbiaceae), is a traditional and neglected Indian fruit with enormous potential for marginal klaste land production. The fruits are nutrient-dense and, after Barbados cheerful, the greatest source of vitamin C among fruits [6]. Methi (Trigonella foenum–graecum l) is a kind of fenugreek (Trigonella foenum– graecum l). It is a leguminous, herbaceous, rained crop and its use in the treatment of both internal and external swellings burns and prevents hair falling [7]. Hibiscus (Hibiscus rosa sinensis, Malvaceae) is helps in hair growth, soft and glossiness. The red flowered variety is preferred in medicine [8]. Avaram Senna (Cassia auriculata linn), commonly known as Tanner’s Cassia is wild and perennial plant. Cassia species are well known for their laxative, purgative constituents and used for skin diseases [9]. Neem is a life-giving tree, especially in the arid coastal and southern areas, and it is used medicinally as an antibiotic, antiseptic, and to treat head lice. It also possesses insecticidal and spermicidal effects and hence kills a wide variety of organisms [10]. Based on the literature, out of 940 study subjects from govt. schools, aged between 8 and 3 y, 156 subjects (16.5%) were found International Journal of Applied Pharmaceutics ISSN- 0975-7058 Thematic Special Issue 2022