Volume 6 • Issue 5• 1000353 J Cytol Histol ISSN: 2157-7099 JCH, an open access journal Research Article Open Access Lin et al., J Cytol Histol 2015, 6:5 DOI: 10.4172/2157-7099.1000353 Case Report Open Access Primary Squamous Cell Carcinoma of the Stomach: Two Case Reports and a Literature Review Yu-Ta Lin 1 , Yang-Yuan Chen 1 *, Sung-Mao Tsai 2 , Jen-Wei Chou 1 , Li-Yuan Bai 3 , Ming-Yu Lien 3 and Tsung-Wei Chen 4 1 Division of Gastroenterology, China Medical University Hospital, China Medical University, Taichung, Taiwan 2 Division of Gastroenterology, Taichung Tzu Chi Hospital, Taiwan 3 Division of Hematology/Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan 4 Department of Pathology, China Medical University Hospital, Taichung, Taiwan *Corresponding author: Yang-Yuan Chen, Division of Gastroenterology, China Medical University, China Medical University Hospital, 3 Lane 138 Tai- An 2nd Street Changhua, 500 Taiwan, China, Tel: 886-4-7359253; E-mail: ychen02@gmail.com Received July 15, 2015; Accepted August 14, 2015; Published August 16, 2015. Citation: Lin YT, Chen YY, Tsai SM, Chou JW, Bai LY, et al. (2015) Primary Squamous Cell Carcinoma of the Stomach: Two Case Reports and a Literature Review. J Cytol Histol 6: 353. doi:10.4172/2157-7099.1000353 Copyright: © 2015 Lin Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Primary squamous cell carcinoma (SCC) of the stomach is rare. In this paper, the patient in Case 1 is a 57-year- old man who underwent partial gastrectomy and adjuvant chemotherapy for primary SCC of the stomach. He survives more than 4 years as of the writing of this report. The patient in Case 2 is a 49-year-old man who was also diagnosed as primary SCC of the stomach. He died of massive gastric cancer bleeding 2 months after the diagnosis. This report is followed by a literature review and further discussion of diagnostic criteria and palliative gastrectomy in these patients. Introduction Gastric cancer is one of the most common cancers worldwide. Te vast majority of gastric cancer is adenocarcinoma, accounting for more than 90% of gastric malignancy. By contrast, primary squamous cell carcinoma (SCC) of the stomach is rare, with an incidence of 0.04–0.07% [1]. In this paper, we report 2 cases of primary SCC of the stomach. Case Report 1 A 57-year-old man was admitted for a 2-week history of dysphagia to solids. He complained of a sensation of throat obstruction seconds afer swallowing food. He had no difculty swallowing liquids, and he experienced no coughing or choking during food consumption. He had smoked one pack of cigarettes daily for the past 30 years. Physical examination provided unremarkable fndings. Furthermore, complete blood count and diferential count as well as liver and renal function test results were all within normal limits. Esophagogastroduodenoscopy (EGD) showed a normal esophagus and esophagogastric (EG) junction; however, a large tumor with central ulceration was noted in the gastric cardia (Figure 1). Endoscopic ultrasound indicated a tumor measuring 3.0 × 4.2 cm and exhibiting heterogeneous echogenicity and a distinct margin. Biopsy of the central ulcerative area revealed moderately diferentiated SCC. Abdominal computerized tomography (CT) indicated central necrosis within this gastric cancer but no evidence of distant metastasis. Te patient was subjected to a positron emission tomography (PET) scan for surveying possible extra-GI tract primary malignancy, and the results demonstrated increased FDG radioactivity only in the gastric cardiac area (Figure 2). On the basis of a diagnosis Figure 1: Upper GI endoscopy of the gastric cardia. The tumor was located in the gastric cardia. Figure 2: The PET-CT scan showed that radioactivity uptake occurred only in the stomach and excluded other primary malignancy origins. Journal of Cytology & Histology J o u r n a l o f C y t o l o g y & H i s t o l o g y ISSN: 2157-7099