Citation: Saeedi, J.A.; AlYafeai, R.H.; AlAbdulSalam, A.M.; Al-Dihan, A.Y.; AlDwaihi, A.A.; Al Harbi, A.A.; Aljadhai, Y.I.; Al-Jedai, A.H.; AlKhawajah, N.M.; Al-Luqmani, M.M.; et al. Saudi Consensus Recommendations on the Management of Multiple Sclerosis: Diagnosis and Radiology/Imaging. Clin. Transl. Neurosci. 2023, 7, 5. https://doi.org/10.3390/ ctn7010005 Academic Editors: Karl-Olof Lovblad and Claudio Bassetti Received: 21 November 2022 Revised: 23 December 2022 Accepted: 5 January 2023 Published: 30 January 2023 Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Review Saudi Consensus Recommendations on the Management of Multiple Sclerosis: Diagnosis and Radiology/Imaging Jameelah A. Saeedi 1 , Rumaiza H. AlYafeai 2 , Abdulaziz M. AlAbdulSalam 3 , Abdulaziz Y. Al-Dihan 4 , Azeeza A. AlDwaihi 5 , Awad A. Al Harbi 1 , Yaser I. Aljadhai 6 , Ahmed H. Al-Jedai 7 , Nuha M. AlKhawajah 8,9 , Majed M. Al-Luqmani 10,11 , Abdulrahman O. AlMalki 12 , Hajer Y. Al-Mudaiheem 7 , Hind A. AlNajashi 13 , Rayan A. AlShareef 14 , Amani A. AlShehri 15 , Faisal Y. AlThekair 16,17 , Nabila S. Ben Slimane 18 , Edward J. Cupler 19 , Mamdouh H. Kalakatawi 20 , Hanaa M. Kedah 21 , Yaser M. Al Malik 16,17 , Ibtisam A. Althubaiti 22 , Reem F. Bunyan 23 , Eslam Shosha 24 and Mohammed A. Al Jumah 25, * 1 Department of Neurology, King Abdullah Bin Abdulaziz University Hospital, King Khalid International Airport Road, Riyadh 11564, Saudi Arabia 2 Department of Neurology, Psychiatry and Psychology, My Clinic International Medical Co., Prince Sultan Road Al Mohammadiyyah, Jeddah 23617, Saudi Arabia 3 Department of Neurology, Prince Sultan Military Medical City, Makkah Al Mukarramah Rd., As Sulimaniyah, Riyadh 12233, Saudi Arabia 4 Department of Radiology and Nuclear Medicine, Security Forces Hospital Program, Riyadh 11481, Saudi Arabia 5 Department of Medicine, King Fahad University Hospital, Al Khobar 34445, Saudi Arabia 6 Department of Neuroimaging and Intervention, King Fahad Medical City, Riyadh 11525, Saudi Arabia 7 Deputyship of Therapeutic Affairs, Ministry of Health, An Nakheel, Riyadh 12382, Saudi Arabia 8 Department of Medicine, King Saud University, Riyadh 12372, Saudi Arabia 9 Division of Neurology, King Saud University Medical City, Riyadh 12372, Saudi Arabia 10 College of Medicine, Taibah University, Janadah Bin Umayyah Road, Tayba, Medina 42353, Saudi Arabia 11 Division of Neurology, King Fahad Hospital, Madinah 42351, Saudi Arabia 12 Neurology Section, Department of Medicine, King Abdulaziz Hospital, Al Mahjar, Jeddah 22421, Saudi Arabia 13 Division of Neurology, Department of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia 14 Department of Ophthalmology, King Abdulaziz University, Jeddah 21589, Saudi Arabia 15 Pharmaceutical Care Services, King Saud Medical City, Riyadh 12746, Saudi Arabia 16 College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Prince Mutib Ibn Abdullah Ibn Abdulaziz Rd., Ar Rimayah, Riyadh 14611, Saudi Arabia 17 Division of Neurology, King Abdulaziz Medical City (National Guard Health Affairs), Prince Mutib Ibn Abdullah Ibn Abdulaziz Rd., Ar Rimayah, Riyadh 11426, Saudi Arabia 18 Drug Information Center, Department of Pharmaceutical Care, King Faisal Specialist Hospital and Research Centre, Jeddah 23431, Saudi Arabia 19 Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Jeddah 23431, Saudi Arabia 20 Department of Neurology, Al Noor Specialist Hospital, An Naseem, Makkah 24241, Saudi Arabia 21 Department of Neurology, Hera General Hospital Industrial City, Al Buhayrat, Makkah 9364, Saudi Arabia 22 Department of Neurology, King Fahad Military Medical Complex Dhahran, Abqaiq Road, Dhahran 31932, Saudi Arabia 23 Department of Neurology, King Fahad Specialist Hospital Dammam, Ammar Bin Thabit Street, Dammam 32253, Saudi Arabia 24 Division of Neurology, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, Canada 25 Department of Neurology, King Fahad Medical City, Riyadh 11525, Saudi Arabia * Correspondence: jumahm@gmail.com Abstract: Multiple sclerosis (MS) is an inflammatory neurological illness common in young adults. The prevalence and incidence of MS are regionally and globally increasing. Recent data from Saudi Arabia (SA) estimate the prevalence to be 40.40 cases per 100,000 population, and 61.95 cases per 100,000 population for Saudi nationals. With the increasing availability of treatment options, new challenges for treatment selection and approaches have emerged. There is a clear need for national guidelines to standardize practice, guide the personalization of decisions, and contain increasing costs. A multidisciplinary expert panel was formed to develop evidence-based Saudi consensus recommendations on the diagnosis and clinical care of MS, to aid healthcare practitioners in advising Clin. Transl. Neurosci. 2023, 7, 5. https://doi.org/10.3390/ctn7010005 https://www.mdpi.com/journal/ctn