Case Report Neuropsychiatric Alterations in a Patient Diagnosed with Advanced Korsakoff’s Syndrome: Clinical Case of Low Incidence and Prevalence in Colombia Carlos Alberto Hurtado Gonzalez , 1,2 Sebastian Ospina Otalvaro, 1 Carlos Steven Marmolejo Escobar, 1 Karen Julieth Quebrada Mera, 1 Pablo Miguel Arango de la Pava, 3 Carlos Andres Clavijo , 4 Lucely Ortega Bolaños, 1,5 NardaR´ ativaHern´ andez, 2,6 AngelicaMariaVidalRosero, 2,6 PaolaAndreaGutierrezLenis, 1 Armando Lucum´ ı, 2 Jean Paul Cappellaro S´ anchez, 2 Angela Agudelo Zamorano, 2,6 Juan Pablo Jacome, 2 Valentina Herrera Montoya, 1 Luis Miguel Saldarriaga, 1 Carolina Prado Salcedo, 2 Sharon Fabiana Alvarado Carranza, 2 Carlos Andres Mar´ ın Hoyos, 2 Juan Pablo Beltran Alomia, 1 Juan Felipe Ayala Rico, 1 Luigui Andres Torres Colorado, 1 and Julia Andrea Arias D´ ıaz 7 1 Research Department, Clinical Neuropsychology, Research Team SEMINEC Cooperativa University, Cali, Colombia 2 Research Department, Department of Medicine and Psychiatry, Research Team Microambiente, Libre University, Cali, Colombia 3 Neurosurgeon Department of Medicine, Del Valle University, Cali, Colombia 4 Neurology, Neurological Institute of the Pacifc, Cali, Colombia 5 Te National Autonomous University of Mexico UNAM, Mexico City, Mexico 6 Specialty of Psychiatry, Libre University, Cali, Colombia  Physical Terapy Program, Faculty of Health and Sports Sciences, University Foundation of the Andean Area, Bogota, Colombia CorrespondenceshouldbeaddressedtoCarlosAlbertoHurtadoGonzalez;carlosalbertopsi@hotmail.com Received 8 April 2022; Revised 10 September 2022; Accepted 20 October 2022; Published 31 December 2022 AcademicEditor:BernardoCarpiniello Copyright©2022CarlosAlbertoHurtadoGonzalezetal.TisisanopenaccessarticledistributedundertheCreativeCommons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properly cited. Korsakof’s syndrome (KS) is an insidious and progressive neuropsychiatric disorder that afects specifc neurocognitive functioning, especially in tasks that require sustained attention, memory, executive functions, and visuospatial functioning. Usually, this disease generates neuropsychiatric complications that worsen the quality of life (QOL) of patients in the medium term.Wepresentacaseofa63•year•oldmalewhopresentedwithadiagnosisofadvancedKorsakof’ssyndromeandhasaclinical history of recurrent memory loss and a history of alcohol abuse. Te patient showed difculty manipulating immediate in• formation, associated with a possible frontal lobe dysfunction, and inability to remember material given through the auditory pathway.Tepatientshowedapsychiatricclinicalpicturewhichisconstantlyworseninghisandhisimmediatecaregiver’sQOL. Tedataobtaineddemonstratethatthepatientpresentsaprogressivecognitiveimpairment,whichintheshorttermiscorrelated withKorsakof•typedementia.Itissuggestedtocarryout functionalneurorehabilitationplansaimedatimprovingtheQOLofthe patient, his immediate caregiver, and future people with this type of diagnosis. Hindawi Case Reports in Medicine Volume 2022, Article ID 2772594, 6 pages https://doi.org/10.1155/2022/2772594