Dharmveer Yadav et al /International Journal of Advances in Scientific Research 2015; 1(05): 233-238. 233 IJASR|VOL 01|ISSUE 05|2015 www.ssjournals.com International Journal of Advances in Scientific Research ISSN: 2395-3616 (Online) Journal DOI: 10.7439/ijasr Research Article Reference Interval for Certain Renal Profile parameters in North Indian Population from Rajasthan Dharmveer Yadav *1 , Monika Gupta 2 , Sandhya Mishra 1 and Praveen Sharma 3 1 Department of Biochemistry, SMS Medical College, Jaipur, India 2 Department of Biochemistry, SN Medical College, Jodhpur, India 3 Department of Biochemistry, AIIMS, Jodhpur, Rajasthan, India *Correspondence Info: Dr. Dharmveer Yadav Department of Biochemistry, SMS Medical College, Jaipur, India E-mail: dharam143s@gmail.com Abstract Objective: Reference intervals are an essential part of laboratory medicine. Current study was planned to evaluate renal parameters in the healthy defined group of individuals which would serve as reference values of renal parameters for the North Indian population from Rajasthan. Design & Methods: Present study was conducted on 2021 apparently healthy individuals of North Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Fasting samples were analyzed for Urea, Creatinine, Uric Acid, Sodium, Potassium and Chloride. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95% confidence interval using SPSS software package version 10.0. Result: RI for Urea, Creatinine and uric acid were lower in female (16-42mg/dl, 0.6-1.2mg/dl, 2.4-6.8mg/dl) as compared to male (17.00-44.35mg/dl, 0.7-1.5mg/dl, 2.8-7.2mg/dl). There was a progressive increase in urea, uric acid and Creatinine with increase in age. Though no appreciable differences could be observed in respect to most of renal parameters in rural versus urban, a wider range for uric acid was observed in urban population (2.50-7.20mg/dl). Except for Na + , K + and Cl - , rest of parameters i.e. urea, creatinine, uric acid were higher range in obese as compared to non obese (17-45 Vs 17-44, 0.66-1.5 Vs 0.60-1.40, 2.5-7.4 Vs 2.5-7.0). Uric acid level was also found to be higher in non vegetarian population (2.6-7.5mg/dl). Conclusion: Findings of this study provide sex, age, BMI, habitat and diet specific renal function reference values to be used for North Indian population. Keywords: Reference Interval, Renal Profile Parameters, North Indian Population. 1. Introduction Reference intervals serve as the basis of laboratory testing and aid the physician in differentiating between the healthy and diseased patient. The population-based reference interval is the most widely used tool for interpretation of individual patient laboratory test results [1]. Reference values are used in interpreting results of laboratory measurements, clinical trials screening and as the basis of safety monitoring for trial participants [2]. These reference values are used to assess health in humans and are based on the effective performance of the major body organs such as the liver, pancreas, heart and kidney. Kidney function tests comprise a variety of individual tests and procedures that can be used to evaluate how well the kidney functions. These tests help to determine if the kidneys are performing their tasks adequately [3]. Measured laboratory parameters are influenced not only by individual factors such as age, sex, and lifestyle, but also by population and ecological factors such as ethnicity, climate, and altitude; they vary not only between individuals but also populations [4]. The reference intervals in use are usually referred from text books or article or values provided by the kit manufacturers. Moreover India is country with extreme seasonal variations, extreme variations in temperature, different dietary habits, life style and physical activity which could affect blood levels of several parameters. There is a need to realize, whether, there is a requirement for restructuring the reference interval for an Indian population [5].