_________________________________________________________________________________________________ *Corresponding author e-mail: amina.mohsen@nahrainuniv.edu.iq; (Amina Mohsen Abass) Receive Date: 17 May 2021, Revise Date: 01 June 2021, Accept Date: 08 June 2021 DOI: 10.21608/ejchem.2021.76542.3749 ©2019 National Information and Documentation Center (NIDOC) Egypt. J. Chem. Vol. 64, No. 11 pp. 6293 - 6300 (2021) Potentiometric Determination of Fexofenadine Hydrochloride Drug by Fabrication of Liquid Membrane Electrodes d Ahmed Ahmed , c TH.Salim AL Rikabi , Haider b Omar Salih Hassan , a Abass Amina M. , Iraq 964 University. Baghdad, + Nahrain - Department of Chemistry, College of Science, Al a,d Iraq. , +964, Department of Chemistry, College of Education for Pure Science, Tikrit University, Tikrit b . Iraq. 964, + Wasit, University, Engineering, Wasit College of , Electrical Engineering Department of c Abstract This paper presents a study in the electrochemical methods for the preparation of three new electrodes of Fexofenadine hydrochloride in a polymeric membrane. The first electrode was prepared from ion pair: molybdophosphoric acid reagent and fexofenadine cation with Di-n-butyl phthalate (DBPH), the subsequent electrode was prepared with O-Nitro phenyl octyl ether (NPOE) and the third electrode was set up by Tri-n-butyl phthalate (TBP), respectively as plasticizer for determination of Fexofenadine hydrochloride drug. Two electrodes indicated a Nernstian response with a slope of [57.01, 56.70] mV. decade −1 for the first and for the second electrodes individually, with detection limits 5.6×10 -6 mole.L -1 for first electrode and 3.5×10 -6 mole.L -1 for the second electrode and the third electrode gave a non Nernstain response equivalent to 14.30 mV.decade −1 . The electrodes FEX -MPA -DBPH, FEX -MPA -NPOE, and FEX -MPA -TBP work adequately over the pH range (2.0-4.5), (2.5-4.0), and (2.0- 4.0) for Fexofenadine hydrochloride electrodes, respectively. The impact of interfering species was insignificant as demonstrated by selectivity coefficient values. The viability of the electrodes FEX -MPA -DBPH, FEX -MPA -NPOE, and FEX -MPA -TBP proceeded in a timeframe (41,36, and 13) days, respectively. The recommended electrodes were successfully used for the determination of Fexofenadine hydrochloride in pure form and pharmaceuticals preparations. This work arrived at excellent outcomes as far as the linearity, and selectivity of the methods. Keywords: Plasticizer, Selectivity; Fexofenadine Hydrochloride; Sensors; Electrochemistry. 1. Introduction The expanding interest in chemical observation in environmental assurance, medication and numerous mechanical cycles have made the requirement for sensors with highlights like high selectivity, affectability, dependability, toughness, the feasibility of automation and remote sensing ability. These requests can regularly be fulfilled by ion selective electrodes ISEs, which are generally applied attributable to their straightforwardness, low coast and quick arrangement of analytical outcomes[1]. Fig. 1. Structural Formula of Fexofenadine HCl. Fexofenadine hydrochloride (Fig1) (RS)-2-[4[1- Hydroxy-4-[4-(hydroxy-diphenyl methyl)-1- piperidyl] butyl]phenyl]-2-methylpropanoic acid. white powder, very easily soluble in ethanol and methanol slightly soluble in water [2], with molecular weight 538.1 g/mole effects of accidental negatively disposed rhinitis containing wheezing nose; runny; and watery eyes or red, irritated, or throat tickling of the nose, or top of the mouth in grown-ups.[3, 4]. Fexofenadine hydrochloride is an antihistamine drug utilized in the fix of roughage fever and comparative sensitivity manifestations [5- 8]. It was made as a substitution of and substitute to terfenadine, an antihistamine with perhaps authentic contraindications. Fexofenadine hydrochloride, like other second and third-age antihistamines, doesn't clearly cross the blood-frontal cortex limit, thusly causes less laziness than interesting histamine- receptor enemies. It works by being an adversary to the H1 receptor. It has been named as both second- age. moreover, third-age[9].Various chemical Egyptian Journal of Chemistry http://ejchem.journals.ekb.eg/ 595