ORIGINAL PAPER Fatigue Experiences Among OCD Outpatients Massimo Pasquini 1 • Daria Piacentino 1 • Isabella Berardelli 1 • Valentina Roselli 1 • Annalisa Maraone 1 • Lorenzo Tarsitani 1 • Massimo Biondi 1 Ó Springer Science+Business Media New York 2015 Abstract Patients with OCD are impaired in multiple domains of functioning and quality of life. While associated psychopathology complaints and neuropsychological deficits were reported, the subjective experience of general fatigue and mental fatigue was scarcely investigated. In this single-center case–control study we compared 50 non-de- pressed OCD outpatients consecutively recruited and 50 panic disorder (PD) outpatients, to determine whether they experienced fatigue differently. Assessment consisted of structured clinical interview for DSM-IV criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using the Yale–Brown Obsessive–Compulsive Scale, the Hamilton Anxiety Rating Scale, the Hamilton Depression Rating Scale, the Clinical Global Impressions Scale, severity and the Global Assessment of Functioning Scale. Fatigue was assessed by using the Multidimensional Fatigue Inventory (MFI). Regarding MFI physical fatigue, an OR of 0.196 (95 % CI 0.080–0.478) was found, suggesting that its presence is associated with lower odds of OCD compared to PD. The same can be said for MFI mental fatigue, as an OR of 0.138 (95 % CI 0.049–0.326) was found, suggesting that its presence is associated with lower odds of OCD. Notably, OCD patients with OCDP co-morbidity reported higher scores of mental fatigue. In this study fatigue, including mental fatigue, seems not to be a prominent experience among adult non- depressed OCD patients. Keywords Obsessive–compulsive disorder Á OCD Á Fatigue Á Mental fatigue Á Panic disorder & Massimo Pasquini massimo.pasquini@uniroma1.it 1 Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell’Universita ` 30, 00185 Rome, Italy 123 Psychiatr Q DOI 10.1007/s11126-015-9357-3