International Journal of Research in Orthopaedics | May-June 2017 | Vol 3 | Issue 3 Page 436 International Journal of Research in Orthopaedics Kadam R et al. Int J Res Orthop. 2017 May;3(3):436-439 http://www.ijoro.org Original Research Article To assess the effects of platelet rich plasma application on pain in osteoarthritis knee Rahul Kadam, Ankit Agrawal*, Abhay Chhallani, Santosh Pandhre, Abhishek Gupta, Ritesh Sawant INTRODUCTION Platelet rich plasma (PRP) is one of the newer methods used to biologically enhance healing. Platelet Rich Plasma is highly concentrate platelets in plasma made from patients own blood after centrifugation. It is known to increase growth factor concentration three to five times of normal plasma and helps to heal the injured tissue. 1,2 Platelet-rich plasma (PRP) is an autologous biologic treatment including patients’ own plasma, containing growth factors released from platelets. 3 The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by a supra-physiologic release of platelet-derived factors directly at the site of treatment. 4 PRP is a minimally invasive therapy approved by the US Food and Drug Administration (FDA) that is used to enhance healing and tissue regeneration. 5 Osteoarthritis knee is a progressive joint disease characterized by joint inflammation and a reparative bone response. Osteoarthritis is characterized by a repetitive inflammatory response of the articular cartilage due to focal loss or erosion of the articular cartilage and a hypertrophy of osteoblastic activity or a reparative bone response known as osteophytosis. 6 The complains in OA knee, such as pain, stiffness of the joints and muscle weakness, are risk factors for mobility limitation leading to impaired quality of life for the affected population. 7 ABSTRACT Background: Platelet rich plasma (PRP) is a concentrate extract of platelets from autologous blood. It is known to increase growth factor of plasma and helps to heal the injured tissue. Platelet-rich plasma (PRP) is an autologous biologic treatment including patients own plasma, containing growth factors released from platelets. The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by an increase release of platelet- derived factors directly at the site of treatment. This study is done to assess the effects of platelet rich plasma application on pain in osteoarthritis knee. Methods: Total of 40 cases was included in this study (18 male and 22 females) with mean age of 57.3 (Range 35- 75). All patients received intra-articular PRP injection. This study was conducted on the patients coming to orthopaedic department at MGM medical college and hospital, Navi Mumbai. Results: In this study it was found that there is decrease in pain on vas pain score, with increasing time. We followed up the patients for period of 3 months. We found that average mean VAS score was decreased from 6.0 to 4.13 after follow up of 3 months after a single dose of intra-articular PRP injection. Conclusions: PRP is an effective treatment for pain in OA knee. It is one of the new approaches in the field of orthopaedics to solve the issues of pain management. Keywords: PRP, Osteoarthritis knee, Intra-articular injection Department of Orthopaedics, MGM Medical College, Navi Mumbai, India Received: 28 February 2017 Revised: 05 March 2017 Accepted: 10 March 2017 *Correspondence: Dr. Ankit Agrawal, E-mail: akki9456@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/issn.2455-4510.IntJResOrthop20171005